Abstract
Duocarmycin-derived seco-cyclopropabenzindole (CBI) drugs have been shown to bind DNA and an aldehyde dehydrogenase (ALDH1A1) in lung cancer cells. The removal of the DNA-binding indole moiety results in a CBI compound that does not bind to DNA in whole cells but still exhibits remarkable cytotoxicity. This CBI compound has an increased affinity for ALDH1A1. Rh=rhodamine.
Originalsprache | Englisch |
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Seiten (von - bis) | 6921-6925 |
Seitenumfang | 5 |
Fachzeitschrift | Angewandte Chemie International Edition in English |
Jahrgang | 52 |
Ausgabenummer | 27 |
DOIs | |
Publikationsstatus | Veröffentlicht - 1 Juli 2013 |