TY - JOUR
T1 - The role of hypoxia inducible factor-1 in cell metabolism - A possible target in cancer therapy
AU - Bel Aiba, Rachida S.
AU - Dimova, Elitsa Y.
AU - Görlach, Agnes
AU - Kietzmann, Thomas
N1 - Funding Information:
The authors apologise to all researchers who excellently contributed to the field and whose work was not cited due to space limitations. This work was supported by grants from the DFG GO709/4-4, the 6th European framework program (EUROXY), Fondation Leducq to AG and by the grants DFG SFB 402 A1, GRK 335, Fonds der Chemischen Indus-trie and Deutsche Krebshilfe 106929 to T Kietzmann. RS Bel Aiba and EY Dimova contributed equally to this paper.
PY - 2006/8
Y1 - 2006/8
N2 - In many cancer types, intratumoural hypoxia is linked to increased expression and activity of the transcription factor hypoxia-inducible factor (HIF-1α), which is associated with poor patient prognosis. This increased the interest in HIF-1α as a cancer drug target. Further, HIF-1α has also a central role in the adaptive cellular programme responding to hypoxia in normal tissues. Many of the HIF-1α-regulated genes encode enzymes of metabolic pathways. Therefore, studying the link and the feedback mechanisms between metabolism and HIF-1α is of major importance to find new and specific therapeutic strategies.
AB - In many cancer types, intratumoural hypoxia is linked to increased expression and activity of the transcription factor hypoxia-inducible factor (HIF-1α), which is associated with poor patient prognosis. This increased the interest in HIF-1α as a cancer drug target. Further, HIF-1α has also a central role in the adaptive cellular programme responding to hypoxia in normal tissues. Many of the HIF-1α-regulated genes encode enzymes of metabolic pathways. Therefore, studying the link and the feedback mechanisms between metabolism and HIF-1α is of major importance to find new and specific therapeutic strategies.
KW - Hypoxia
KW - Hypoxia-inducible factor
KW - von Hippel-Lindau rumour suppressor
UR - http://www.scopus.com/inward/record.url?scp=33746748089&partnerID=8YFLogxK
U2 - 10.1517/14728222.10.4.583
DO - 10.1517/14728222.10.4.583
M3 - Review article
C2 - 16848694
AN - SCOPUS:33746748089
SN - 1472-8222
VL - 10
SP - 583
EP - 599
JO - Expert Opinion on Therapeutic Targets
JF - Expert Opinion on Therapeutic Targets
IS - 4
ER -
