The role of growth factors in central nervous system tumours

Carsten Nieder; Juergen Schlegel; Nicolaus Andratschke; Reinhard Thamm; Anca L. Grosu; Michael Molls

The role of growth factors in central nervous system tumours

Carsten Nieder, Juergen Schlegel, Nicolaus Andratschke, Reinhard Thamm, Anca L. Grosu, Michael Molls

TUM Institute for Advanced Study

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

18 Zitate (Scopus)

Abstract

The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF-β, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.

Originalsprache	Englisch
Seiten (von - bis)	1681-1686
Seitenumfang	6
Fachzeitschrift	Anticancer Research
Jahrgang	23
Ausgabenummer	2 C
Publikationsstatus	Veröffentlicht - März 2003

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abstract = "The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF-β, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.",

keywords = "Brain tumours, Glioblastoma multiforme, Glioma, Growth factors, Meningioma, Prognostic factors, Radiotherapy",

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AU - Nieder, Carsten

AU - Schlegel, Juergen

AU - Andratschke, Nicolaus

AU - Thamm, Reinhard

AU - Grosu, Anca L.

AU - Molls, Michael

PY - 2003/3

Y1 - 2003/3

N2 - The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF-β, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.

AB - The role of growth factors in tumour growth and progression has increasingly been studied over the last few years. This review summarizes the available data and discusses their limitations as well as their potential influence on future therapeutic strategies. A large body of data suggests an important role of EGF, TGF-β, PDGF and VEGF ligands and receptors in the vascularization of several brain tumour types, including gliomas and meningiomas. Recent experimental data indicate that inhibition of the signalling pathways may represent promising therapeutic strategies. Some inhibitory agents have now entered clinical trials, mainly for recurrent gliomas. Early results are presented.

KW - Brain tumours

KW - Glioblastoma multiforme

KW - Glioma

KW - Growth factors

KW - Meningioma

KW - Prognostic factors

KW - Radiotherapy

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M3 - Review article

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AN - SCOPUS:0038200666

SN - 0250-7005

VL - 23

SP - 1681

EP - 1686

JO - Anticancer Research

JF - Anticancer Research

IS - 2 C

ER -

The role of growth factors in central nervous system tumours

Abstract

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