The role of exhaustion in CAR T cell therapy

Greg M. Delgoffe; Chenqi Xu; Crystal L. Mackall; Michael R. Green; Stephen Gottschalk; Daniel E. Speiser; Dietmar Zehn; Paul A. Beavis

doi:10.1016/j.ccell.2021.06.012

The role of exhaustion in CAR T cell therapy

Greg M. Delgoffe, Chenqi Xu, Crystal L. Mackall, Michael R. Green, Stephen Gottschalk, Daniel E. Speiser, Dietmar Zehn, Paul A. Beavis

Lehrstuhl für Tierphysiologie und Immunologie

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

49 Zitate (Scopus)

Abstract

CAR T cell therapy successes are challenged by several mechanisms of resistance including the development of dysfunctional states such as exhaustion. The features of CAR T cell exhaustion, its role in limiting the efficacy of CAR T therapy in both liquid and solid malignancies, and potential strategies to overcome it are discussed.

Originalsprache	Englisch
Seiten (von - bis)	885-888
Seitenumfang	4
Fachzeitschrift	Cancer Cell
Jahrgang	39
Ausgabenummer	7
DOIs	https://doi.org/10.1016/j.ccell.2021.06.012
Publikationsstatus	Veröffentlicht - 12 Juli 2021

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10.1016/j.ccell.2021.06.012

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author = "Delgoffe, {Greg M.} and Chenqi Xu and Mackall, {Crystal L.} and Green, {Michael R.} and Stephen Gottschalk and Speiser, {Daniel E.} and Dietmar Zehn and Beavis, {Paul A.}",

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AU - Speiser, Daniel E.

AU - Zehn, Dietmar

AU - Beavis, Paul A.

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The role of exhaustion in CAR T cell therapy

Abstract

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