TY - JOUR
T1 - The phytoalexins from cultivated and wild crucifers
T2 - Chemistry and biology
AU - Pedras, M. Soledade C.
AU - Yaya, Estifanos E.
AU - Glawischnig, Erich
PY - 2011/8
Y1 - 2011/8
N2 - Phytoalexins are antimicrobial secondary metabolites produced de novo by plants in response to stress, including microbial attack. In general, phytoalexins are important components of plant defenses against fungal and bacterial pathogens. The phytoalexins of crucifers are indole alkaloids derived from (S)-tryptophan, most of which contain a sulfur atom derived from cysteine. Beside their antimicrobial activity against different plant pathogenic species, cruciferous phytoalexins have shown anticarcinogenic effects on various human cell lines. This review focuses on the phytoalexins produced by cruciferous plants reported to date, with particular emphasis on their chemical synthesis, biosynthesis, metabolism by plant fungal pathogens and biological activities. A summary table containing all phytoalexins, their cultivated and wild cruciferous sources, their synthetic starting materials, biotransformation products and biological activities is provided.
AB - Phytoalexins are antimicrobial secondary metabolites produced de novo by plants in response to stress, including microbial attack. In general, phytoalexins are important components of plant defenses against fungal and bacterial pathogens. The phytoalexins of crucifers are indole alkaloids derived from (S)-tryptophan, most of which contain a sulfur atom derived from cysteine. Beside their antimicrobial activity against different plant pathogenic species, cruciferous phytoalexins have shown anticarcinogenic effects on various human cell lines. This review focuses on the phytoalexins produced by cruciferous plants reported to date, with particular emphasis on their chemical synthesis, biosynthesis, metabolism by plant fungal pathogens and biological activities. A summary table containing all phytoalexins, their cultivated and wild cruciferous sources, their synthetic starting materials, biotransformation products and biological activities is provided.
UR - http://www.scopus.com/inward/record.url?scp=79960799366&partnerID=8YFLogxK
U2 - 10.1039/c1np00020a
DO - 10.1039/c1np00020a
M3 - Article
C2 - 21681321
AN - SCOPUS:79960799366
SN - 0265-0568
VL - 28
SP - 1381
EP - 1405
JO - Natural Product Reports
JF - Natural Product Reports
IS - 8
ER -