The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer

Eva Lichtenegger, Florestan Koll, Helena Haas, Klaus Mantwill, Klaus Peter Janssen, Melanie Laschinger, Jürgen Gschwend, Katja Steiger, Peter C. Black, Igor Moskalev, Roman Nawroth, Per Sonne Holm

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

19 Zitate (Scopus)

Abstract

Muscle-invasive bladder cancer represents approximately 25% of diagnosed bladder cancer cases and carries a significant risk of death. Oncolytic viruses are novel antitumor agents with the ability to selectively replicate and lyse tumor cells while sparing healthy tissue. We explored the efficiency of the oncolytic YB-1-selective adenovirus XVir-N-31 in vitro and in an orthotopic mouse model for bladder cancer by intramural injection under ultrasound guidance. We demonstrated that XVir-N-31 replicated in bladder cancer cells and induced a stronger immunogenic cell death than wild-type adenovirus by facilitating enhanced release of HMGB1 and exosomal Hsp70. The intratumoral delivery of XVir-N-31 by ultrasound guidance delayed tumor growth in an immunodeficient model, demonstrating the feasibility of this approach to deliver oncolytic viruses directly into the tumor.

OriginalspracheEnglisch
Seiten (von - bis)44-56
Seitenumfang13
FachzeitschriftHuman Gene Therapy
Jahrgang30
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - Jan. 2019

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