The Knockout Mouse Project

Christopher P. Austin; James F. Battey; Allan Bradley; Maja Bucan; Mario Capecchi; Francis S. Collins; William F. Dove; Geoffrey Duyk; Susan Dymecki; Janan T. Eppig; Franziska B. Grieder; Nathaniel Heintz; Geoff Hicks; Thomas R. Insel; Alexandra Joyner; Beverly H. Koller; K. C.Kent Lloyd; Terry Magnuson; Mark W. Moore; Andras Nagy; Jonathan D. Pollock; Allen D. Roses; Arthur T. Sands; Brian Seed; William C. Skarnes; Jay Snoddy; Philippe Soriano; David J. Stewart; Francis Stewart; Bruce Stillman; Harold Varmus; Lyuba Varticovski; Inder M. Verma; Thomas F. Vogt; Harald Von Melchner; Jan Witkowski; Richard P. Woychik; Wolfgang Wurst; George D. Yancopoulos; Stephen G. Young; Brian Zambrowicz

doi:10.1038/ng0904-921

The Knockout Mouse Project

Christopher P. Austin, James F. Battey, Allan Bradley, Maja Bucan, Mario Capecchi, Francis S. Collins, William F. Dove, Geoffrey Duyk, Susan Dymecki, Janan T. Eppig, Franziska B. Grieder, Nathaniel Heintz, Geoff Hicks, Thomas R. Insel, Alexandra Joyner, Beverly H. Koller, K. C.Kent Lloyd, Terry Magnuson, Mark W. Moore, Andras NagyJonathan D. Pollock, Allen D. Roses, Arthur T. Sands, Brian Seed, William C. Skarnes, Jay Snoddy, Philippe Soriano, David J. Stewart, Francis Stewart, Bruce Stillman, Harold Varmus, Lyuba Varticovski, Inder M. Verma, Thomas F. Vogt, Harald Von Melchner, Jan Witkowski, Richard P. Woychik, Wolfgang Wurst, George D. Yancopoulos, Stephen G. Young, Brian Zambrowicz

Publikation: Beitrag in Fachzeitschrift › Kommentar/Debatte

520 Zitate (Scopus)

Abstract

Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

Originalsprache	Englisch
Seiten (von - bis)	921-924
Seitenumfang	4
Fachzeitschrift	Nature Genetics
Jahrgang	36
Ausgabenummer	9
DOIs	https://doi.org/10.1038/ng0904-921
Publikationsstatus	Veröffentlicht - Sept. 2004
Extern publiziert	Ja

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Austin, C. P., Battey, J. F., Bradley, A., Bucan, M., Capecchi, M., Collins, F. S., Dove, W. F., Duyk, G., Dymecki, S., Eppig, J. T., Grieder, F. B., Heintz, N., Hicks, G., Insel, T. R., Joyner, A., Koller, B. H., Lloyd, K. C. K., Magnuson, T., Moore, M. W., ... Zambrowicz, B. (2004). The Knockout Mouse Project. Nature Genetics, 36(9), 921-924. https://doi.org/10.1038/ng0904-921

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title = "The Knockout Mouse Project",

abstract = "Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.",

author = "Austin, {Christopher P.} and Battey, {James F.} and Allan Bradley and Maja Bucan and Mario Capecchi and Collins, {Francis S.} and Dove, {William F.} and Geoffrey Duyk and Susan Dymecki and Eppig, {Janan T.} and Grieder, {Franziska B.} and Nathaniel Heintz and Geoff Hicks and Insel, {Thomas R.} and Alexandra Joyner and Koller, {Beverly H.} and Lloyd, {K. C.Kent} and Terry Magnuson and Moore, {Mark W.} and Andras Nagy and Pollock, {Jonathan D.} and Roses, {Allen D.} and Sands, {Arthur T.} and Brian Seed and Skarnes, {William C.} and Jay Snoddy and Philippe Soriano and Stewart, {David J.} and Francis Stewart and Bruce Stillman and Harold Varmus and Lyuba Varticovski and Verma, {Inder M.} and Vogt, {Thomas F.} and {Von Melchner}, Harald and Jan Witkowski and Woychik, {Richard P.} and Wolfgang Wurst and Yancopoulos, {George D.} and Young, {Stephen G.} and Brian Zambrowicz",

year = "2004",

month = sep,

doi = "10.1038/ng0904-921",

language = "English",

volume = "36",

pages = "921--924",

journal = "Nature Genetics",

issn = "1061-4036",

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Austin, CP, Battey, JF, Bradley, A, Bucan, M, Capecchi, M, Collins, FS, Dove, WF, Duyk, G, Dymecki, S, Eppig, JT, Grieder, FB, Heintz, N, Hicks, G, Insel, TR, Joyner, A, Koller, BH, Lloyd, KCK, Magnuson, T, Moore, MW, Nagy, A, Pollock, JD, Roses, AD, Sands, AT, Seed, B, Skarnes, WC, Snoddy, J, Soriano, P, Stewart, DJ, Stewart, F, Stillman, B, Varmus, H, Varticovski, L, Verma, IM, Vogt, TF, Von Melchner, H, Witkowski, J, Woychik, RP, Wurst, W, Yancopoulos, GD, Young, SG & Zambrowicz, B 2004, 'The Knockout Mouse Project', Nature Genetics, Jg. 36, Nr. 9, S. 921-924. https://doi.org/10.1038/ng0904-921

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T1 - The Knockout Mouse Project

AU - Austin, Christopher P.

AU - Battey, James F.

AU - Bradley, Allan

AU - Bucan, Maja

AU - Capecchi, Mario

AU - Collins, Francis S.

AU - Dove, William F.

AU - Duyk, Geoffrey

AU - Dymecki, Susan

AU - Eppig, Janan T.

AU - Grieder, Franziska B.

AU - Heintz, Nathaniel

AU - Hicks, Geoff

AU - Insel, Thomas R.

AU - Joyner, Alexandra

AU - Koller, Beverly H.

AU - Lloyd, K. C.Kent

AU - Magnuson, Terry

AU - Moore, Mark W.

AU - Nagy, Andras

AU - Pollock, Jonathan D.

AU - Roses, Allen D.

AU - Sands, Arthur T.

AU - Seed, Brian

AU - Skarnes, William C.

AU - Snoddy, Jay

AU - Soriano, Philippe

AU - Stewart, David J.

AU - Stewart, Francis

AU - Stillman, Bruce

AU - Varmus, Harold

AU - Varticovski, Lyuba

AU - Verma, Inder M.

AU - Vogt, Thomas F.

AU - Von Melchner, Harald

AU - Witkowski, Jan

AU - Woychik, Richard P.

AU - Wurst, Wolfgang

AU - Yancopoulos, George D.

AU - Young, Stephen G.

AU - Zambrowicz, Brian

PY - 2004/9

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N2 - Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

AB - Mouse knockout technology provides a powerful means of elucidating gene function in vivo, and a publicly available genome-wide collection of mouse knockouts would be significantly enabling for biomedical discovery. To date, published knockouts exist for only about 10% of mouse genes. Furthermore, many of these are limited in utility because they have not been made or phenotyped in standardized ways, and many are not freely available to researchers. It is time to harness new technologies and efficiencies of production to mount a high-throughput international effort to produce and phenotype knockouts for all mouse genes, and place these resources into the public domain.

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U2 - 10.1038/ng0904-921

DO - 10.1038/ng0904-921

M3 - Comment/debate

C2 - 15340423

AN - SCOPUS:4444262688

SN - 1061-4036

VL - 36

SP - 921

EP - 924

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

The Knockout Mouse Project

Abstract

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