The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Franziska Greulich; Michael Wierer; Aikaterini Mechtidou; Omar Gonzalez-Garcia; N. Henriette Uhlenhaut

doi:10.1016/j.celrep.2021.108742

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Franziska Greulich
, Michael Wierer
, Aikaterini Mechtidou
, Omar Gonzalez-Garcia
, N. Henriette Uhlenhaut

Professur für Metabolic Programming

German Centre for Diabetes Research (DZD)
Max Planck Institute of Biochemistry
University of Munich

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

32 Zitate (Scopus)

Abstract

Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.

Originalsprache	Englisch
Aufsatznummer	108742
Fachzeitschrift	Cell Reports
Jahrgang	34
Ausgabenummer	6
DOIs	https://doi.org/10.1016/j.celrep.2021.108742
Publikationsstatus	Veröffentlicht - 9 Feb. 2021

Zugriff auf Dokument

10.1016/j.celrep.2021.108742

Andere Dateien und Links

Verknüpfung zur Publikation in Scopus

Dieses zitieren

@article{8d56190035964b918bd49ac0d4a57418,

title = "The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers",

abstract = "Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.",

keywords = "COMPASS complex, H3K4 methylation, SETD1A, dexamethasone, enhancers, genomics, glucocorticoid receptor, inflammation, macrophages, transcription",

author = "Franziska Greulich and Michael Wierer and Aikaterini Mechtidou and Omar Gonzalez-Garcia and Uhlenhaut, \{N. Henriette\}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = feb,

day = "9",

doi = "10.1016/j.celrep.2021.108742",

language = "English",

volume = "34",

journal = "Cell Reports",

issn = "2639-1856",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

AU - Greulich, Franziska

AU - Wierer, Michael

AU - Mechtidou, Aikaterini

AU - Gonzalez-Garcia, Omar

AU - Uhlenhaut, N. Henriette

PY - 2021/2/9

Y1 - 2021/2/9

N2 - Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.

AB - Glucocorticoids such as dexamethasone are widely used immunomodulators. Combining proteomics, ChIP-seq, RNA-seq, and genetic loss-of-function studies in murine macrophages, Greulich et al. show that recruitment of the SETD1A/COMPASS complex to cis-regulatory elements by the glucocorticoid receptor mediates some of their anti-inflammatory actions.

KW - COMPASS complex

KW - H3K4 methylation

KW - SETD1A

KW - dexamethasone

KW - enhancers

KW - genomics

KW - glucocorticoid receptor

KW - inflammation

KW - macrophages

KW - transcription

UR - https://www.scopus.com/pages/publications/85100505103

U2 - 10.1016/j.celrep.2021.108742

DO - 10.1016/j.celrep.2021.108742

M3 - Article

C2 - 33567280

AN - SCOPUS:85100505103

SN - 2639-1856

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 6

M1 - 108742

ER -

The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers

Abstract

Zugriff auf Dokument

Andere Dateien und Links

Fingerprint

Dieses zitieren