The effect of insulin-like growth factor-I, relaxin and luteinizing hormone on vascular endothelial growth factor secretion by cultured endometrial stromal cells on different days of early pregnancy in pigs

Monika M. Kaczmarek, Agnieszka Blitek, Dieter Schams, Adam J. Ziecik

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

14 Zitate (Scopus)

Abstract

The effect of insulin-like growth factor-I (IGF-I), relaxin (RLX) and luteinizing hormone (LH) on vascular endothelial growth factor (VEGF) in vitro secretion by endometrial stromal cells in pigs was investigated on days 10-12 and 20-22 of gestation. LH-stimulated stromal cell secretion of VEGF did not differ among tested days of early pregnancy. However, IGF-I- and RLX-mediated release of VEGF depended on the day of pregnancy. It seems that IGF-I and RLX may be considered as potent activators of VEGF-mediated angiogenesis in porcine endometrium, and their action may be more pronounced during maternal recognition of pregnancy.

OriginalspracheEnglisch
Seiten (von - bis)163-170
Seitenumfang8
FachzeitschriftReproductive biology
Jahrgang8
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - Juli 2008

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