The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul; Yenni A. Garcia; Bettina Zierer; Chaitanya Patwardhan; Omar Gutierrez; Zacariah Hildenbrand; Diondra C. Harris; Heather A. Balsiger; Jeffrey C. Sivils; Jill L. Johnson; Johannes Buchner; Ahmed Chadli; Marc B. Cox

doi:10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

Atanu Paul
, Yenni A. Garcia
, Bettina Zierer
, Chaitanya Patwardhan
, Omar Gutierrez
, Zacariah Hildenbrand
, Diondra C. Harris
, Heather A. Balsiger
, Jeffrey C. Sivils
, Jill L. Johnson
, Johannes Buchner
, Ahmed Chadli
, Marc B. Cox

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

28 Zitate (Scopus)

Abstract

Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

Originalsprache	Englisch
Seiten (von - bis)	15297-15308
Seitenumfang	12
Fachzeitschrift	Journal of Biological Chemistry
Jahrgang	289
Ausgabenummer	22
DOIs	https://doi.org/10.1074/jbc.M113.535229
Publikationsstatus	Veröffentlicht - 30 Mai 2014
Extern publiziert	Ja

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10.1074/jbc.M113.535229

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Paul, A., Garcia, Y. A., Zierer, B., Patwardhan, C., Gutierrez, O., Hildenbrand, Z., Harris, D. C., Balsiger, H. A., Sivils, J. C., Johnson, J. L., Buchner, J., Chadli, A., & Cox, M. B. (2014). The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. Journal of Biological Chemistry, 289(22), 15297-15308. https://doi.org/10.1074/jbc.M113.535229

@article{41f222042b43442986eed1d107fb6eef,

title = "The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors",

abstract = "Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.",

author = "Atanu Paul and Garcia, \{Yenni A.\} and Bettina Zierer and Chaitanya Patwardhan and Omar Gutierrez and Zacariah Hildenbrand and Harris, \{Diondra C.\} and Balsiger, \{Heather A.\} and Sivils, \{Jeffrey C.\} and Johnson, \{Jill L.\} and Johannes Buchner and Ahmed Chadli and Cox, \{Marc B.\}",

year = "2014",

month = may,

day = "30",

doi = "10.1074/jbc.M113.535229",

language = "English",

volume = "289",

pages = "15297--15308",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "22",

}

Paul, A, Garcia, YA, Zierer, B, Patwardhan, C, Gutierrez, O, Hildenbrand, Z, Harris, DC, Balsiger, HA, Sivils, JC, Johnson, JL, Buchner, J, Chadli, A & Cox, MB 2014, 'The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors', Journal of Biological Chemistry, Jg. 289, Nr. 22, S. 15297-15308. https://doi.org/10.1074/jbc.M113.535229

The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors. / Paul, Atanu; Garcia, Yenni A.; Zierer, Bettina et al.
in: Journal of Biological Chemistry, Jahrgang 289, Nr. 22, 30.05.2014, S. 15297-15308.

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

TY - JOUR

T1 - The cochaperone SGTA (small glutamine-rich tetratricopeptide repeat-containing protein alpha) demonstrates regulatory specificity for the androgen, glucocorticoid, and progesterone receptors

AU - Paul, Atanu

AU - Garcia, Yenni A.

AU - Zierer, Bettina

AU - Patwardhan, Chaitanya

AU - Gutierrez, Omar

AU - Hildenbrand, Zacariah

AU - Harris, Diondra C.

AU - Balsiger, Heather A.

AU - Sivils, Jeffrey C.

AU - Johnson, Jill L.

AU - Buchner, Johannes

AU - Chadli, Ahmed

AU - Cox, Marc B.

PY - 2014/5/30

Y1 - 2014/5/30

N2 - Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

AB - Background: Cochaperones are important for the folding and activation of steroid hormone receptors. Results: The androgen receptor-associated cochaperone SGTA binds both Hsp70 and Hsp90 and regulates progesterone and glucocorticoid receptors. Conclusion: SGTA is a receptor-specific cochaperone that regulates distinct steps in the receptor chaperoning cycle. Significance: SGTA is a relevant factor in diseases that depend on androgens, progestins and/or glucocorticoids.

UR - https://www.scopus.com/pages/publications/84901720583

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DO - 10.1074/jbc.M113.535229

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AN - SCOPUS:84901720583

SN - 0021-9258

VL - 289

SP - 15297

EP - 15308

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 22

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