Taurine deficiency as a driver of aging

Parminder Singh; Kishore Gollapalli; Stefano Mangiola; Daniela Schranner; Mohd Aslam Yusuf; Manish Chamoli; Sting L. Shi; Bruno Lopes Bastos; Tripti Nair; Annett Riermeier; Elena M. Vayndorf; Judy Z. Wu; Aishwarya Nilakhe; Christina Q. Nguyen; Michael Muir; Michael G. Kiflezghi; Anna Foulger; Alex Junker; Jack Devine; Kunal Sharan; Shankar J. Chinta; Swati Rajput; Anand Rane; Philipp Baumert; Martin Schönfelder; Francescopaolo Iavarone; Giorgia di Lorenzo; Swati Kumari; Alka Gupta; Rajesh Sarkar; Costerwell Khyriem; Amanpreet S. Chawla; Ankur Sharma; Nazan Sarper; Naibedya Chattopadhyay; Bichitra K. Biswal; Carmine Settembre; Perumal Nagarajan; Kimara L. Targoff; Martin Picard; Sarika Gupta; Vidya Velagapudi; Anthony T. Papenfuss; Alaattin Kaya; Miguel Godinho Ferreira; Brian K. Kennedy; Julie K. Andersen; Gordon J. Lithgow; Abdullah Mahmood Ali; Arnab Mukhopadhyay; Aarno Palotie; Gabi Kastenmüller; Matt Kaeberlein; Henning Wackerhage; Bhupinder Pal; Vijay K. Yadav

doi:10.1126/science.abn9257

Taurine deficiency as a driver of aging

Parminder Singh, Kishore Gollapalli, Stefano Mangiola, Daniela Schranner, Mohd Aslam Yusuf, Manish Chamoli, Sting L. Shi, Bruno Lopes Bastos, Tripti Nair, Annett Riermeier, Elena M. Vayndorf, Judy Z. Wu, Aishwarya Nilakhe, Christina Q. Nguyen, Michael Muir, Michael G. Kiflezghi, Anna Foulger, Alex Junker, Jack Devine, Kunal SharanShankar J. Chinta, Swati Rajput, Anand Rane, Philipp Baumert, Martin Schönfelder, Francescopaolo Iavarone, Giorgia di Lorenzo, Swati Kumari, Alka Gupta, Rajesh Sarkar, Costerwell Khyriem, Amanpreet S. Chawla, Ankur Sharma, Nazan Sarper, Naibedya Chattopadhyay, Bichitra K. Biswal, Carmine Settembre, Perumal Nagarajan, Kimara L. Targoff, Martin Picard, Sarika Gupta, Vidya Velagapudi, Anthony T. Papenfuss, Alaattin Kaya, Miguel Godinho Ferreira, Brian K. Kennedy, Julie K. Andersen, Gordon J. Lithgow, Abdullah Mahmood Ali, Arnab Mukhopadhyay, Aarno Palotie, Gabi Kastenmüller, Matt Kaeberlein, Henning Wackerhage, Bhupinder Pal, Vijay K. Yadav

Professur für Sportbiologie

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

86 Zitate (Scopus)

Abstract

Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

Originalsprache	Englisch
Aufsatznummer	eabn9257
Fachzeitschrift	Science
Jahrgang	380
Ausgabenummer	6649
DOIs	https://doi.org/10.1126/science.abn9257
Publikationsstatus	Veröffentlicht - 9 Juni 2023

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10.1126/science.abn9257

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Singh, P., Gollapalli, K., Mangiola, S., Schranner, D., Yusuf, M. A., Chamoli, M., Shi, S. L., Bastos, B. L., Nair, T., Riermeier, A., Vayndorf, E. M., Wu, J. Z., Nilakhe, A., Nguyen, C. Q., Muir, M., Kiflezghi, M. G., Foulger, A., Junker, A., Devine, J., ... Yadav, V. K. (2023). Taurine deficiency as a driver of aging. Science, 380(6649), Artikel eabn9257. https://doi.org/10.1126/science.abn9257

@article{c418e2499f254e6aacfe2ceb174a1774,

title = "Taurine deficiency as a driver of aging",

abstract = "Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.",

author = "Parminder Singh and Kishore Gollapalli and Stefano Mangiola and Daniela Schranner and Yusuf, {Mohd Aslam} and Manish Chamoli and Shi, {Sting L.} and Bastos, {Bruno Lopes} and Tripti Nair and Annett Riermeier and Vayndorf, {Elena M.} and Wu, {Judy Z.} and Aishwarya Nilakhe and Nguyen, {Christina Q.} and Michael Muir and Kiflezghi, {Michael G.} and Anna Foulger and Alex Junker and Jack Devine and Kunal Sharan and Chinta, {Shankar J.} and Swati Rajput and Anand Rane and Philipp Baumert and Martin Sch{\"o}nfelder and Francescopaolo Iavarone and {di Lorenzo}, Giorgia and Swati Kumari and Alka Gupta and Rajesh Sarkar and Costerwell Khyriem and Chawla, {Amanpreet S.} and Ankur Sharma and Nazan Sarper and Naibedya Chattopadhyay and Biswal, {Bichitra K.} and Carmine Settembre and Perumal Nagarajan and Targoff, {Kimara L.} and Martin Picard and Sarika Gupta and Vidya Velagapudi and Papenfuss, {Anthony T.} and Alaattin Kaya and Ferreira, {Miguel Godinho} and Kennedy, {Brian K.} and Andersen, {Julie K.} and Lithgow, {Gordon J.} and Ali, {Abdullah Mahmood} and Arnab Mukhopadhyay and Aarno Palotie and Gabi Kastenm{\"u}ller and Matt Kaeberlein and Henning Wackerhage and Bhupinder Pal and Yadav, {Vijay K.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2023 the authors, some rights reserved.",

year = "2023",

month = jun,

day = "9",

doi = "10.1126/science.abn9257",

language = "English",

volume = "380",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6649",

}

Singh, P, Gollapalli, K, Mangiola, S, Schranner, D, Yusuf, MA, Chamoli, M, Shi, SL, Bastos, BL, Nair, T, Riermeier, A, Vayndorf, EM, Wu, JZ, Nilakhe, A, Nguyen, CQ, Muir, M, Kiflezghi, MG, Foulger, A, Junker, A, Devine, J, Sharan, K, Chinta, SJ, Rajput, S, Rane, A, Baumert, P, Schönfelder, M, Iavarone, F, di Lorenzo, G, Kumari, S, Gupta, A, Sarkar, R, Khyriem, C, Chawla, AS, Sharma, A, Sarper, N, Chattopadhyay, N, Biswal, BK, Settembre, C, Nagarajan, P, Targoff, KL, Picard, M, Gupta, S, Velagapudi, V, Papenfuss, AT, Kaya, A, Ferreira, MG, Kennedy, BK, Andersen, JK, Lithgow, GJ, Ali, AM, Mukhopadhyay, A, Palotie, A, Kastenmüller, G, Kaeberlein, M, Wackerhage, H, Pal, B & Yadav, VK 2023, 'Taurine deficiency as a driver of aging', Science, Jg. 380, Nr. 6649, eabn9257. https://doi.org/10.1126/science.abn9257

TY - JOUR

T1 - Taurine deficiency as a driver of aging

AU - Singh, Parminder

AU - Gollapalli, Kishore

AU - Mangiola, Stefano

AU - Schranner, Daniela

AU - Yusuf, Mohd Aslam

AU - Chamoli, Manish

AU - Shi, Sting L.

AU - Bastos, Bruno Lopes

AU - Nair, Tripti

AU - Riermeier, Annett

AU - Vayndorf, Elena M.

AU - Wu, Judy Z.

AU - Nilakhe, Aishwarya

AU - Nguyen, Christina Q.

AU - Muir, Michael

AU - Kiflezghi, Michael G.

AU - Foulger, Anna

AU - Junker, Alex

AU - Devine, Jack

AU - Sharan, Kunal

AU - Chinta, Shankar J.

AU - Rajput, Swati

AU - Rane, Anand

AU - Baumert, Philipp

AU - Schönfelder, Martin

AU - Iavarone, Francescopaolo

AU - di Lorenzo, Giorgia

AU - Kumari, Swati

AU - Gupta, Alka

AU - Sarkar, Rajesh

AU - Khyriem, Costerwell

AU - Chawla, Amanpreet S.

AU - Sharma, Ankur

AU - Sarper, Nazan

AU - Chattopadhyay, Naibedya

AU - Biswal, Bichitra K.

AU - Settembre, Carmine

AU - Nagarajan, Perumal

AU - Targoff, Kimara L.

AU - Picard, Martin

AU - Gupta, Sarika

AU - Velagapudi, Vidya

AU - Papenfuss, Anthony T.

AU - Kaya, Alaattin

AU - Ferreira, Miguel Godinho

AU - Kennedy, Brian K.

AU - Andersen, Julie K.

AU - Lithgow, Gordon J.

AU - Ali, Abdullah Mahmood

AU - Mukhopadhyay, Arnab

AU - Palotie, Aarno

AU - Kastenmüller, Gabi

AU - Kaeberlein, Matt

AU - Wackerhage, Henning

AU - Pal, Bhupinder

AU - Yadav, Vijay K.

PY - 2023/6/9

Y1 - 2023/6/9

N2 - Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

AB - Aging is associated with changes in circulating levels of various molecules, some of which remain undefined. We find that concentrations of circulating taurine decline with aging in mice, monkeys, and humans. A reversal of this decline through taurine supplementation increased the health span (the period of healthy living) and life span in mice and health span in monkeys. Mechanistically, taurine reduced cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammaging. In humans, lower taurine concentrations correlated with several age-related diseases and taurine concentrations increased after acute endurance exercise. Thus, taurine deficiency may be a driver of aging because its reversal increases health span in worms, rodents, and primates and life span in worms and rodents. Clinical trials in humans seem warranted to test whether taurine deficiency might drive aging in humans.

UR - http://www.scopus.com/inward/record.url?scp=85163908065&partnerID=8YFLogxK

U2 - 10.1126/science.abn9257

DO - 10.1126/science.abn9257

M3 - Article

C2 - 37289866

AN - SCOPUS:85163908065

SN - 0036-8075

VL - 380

JO - Science

JF - Science

IS - 6649

M1 - eabn9257

ER -

Taurine deficiency as a driver of aging

Abstract

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