Targeted truncation of the ADAM17 cytoplasmic domain in mice results in protein destabilization and a hypomorphic phenotype

Keyphrases

• Truncation 100%
• Cytoplasmic Domain 100%
• Metalloprotease 100%
• Hypomorphic mutation 100%
• Disintegrin 100%
• Protein Destabilization 100%
• Protein Level 16%
• ADAM17 16%
• Post-translational 8%
• Signaling Pathway 8%
• Adulthood 8%
• Eyes Open 8%
• Mouse Embryonic Fibroblasts 8%
• Heart Valve 8%
• Cell Surface 8%
• Bone Growth 8%
• Epidermal Growth Factor Receptor 8%
• Functional Assay 8%
• Tumor Necrosis Factor-α 8%
• Cas9 Protein 8%
• Reduced Protein 8%
• Transmembrane Domain 8%
• At Birth 8%
• Interleukin-6 Receptor (IL-6R) 8%
• Epidermal Growth Factor Receptor Signaling 8%
• Bone Marrow-derived Macrophages 8%
• Rapid Response 8%
• Whisker 8%
• Semilunar 8%
• Plate Defects 8%
• Sheddase 8%
• Woolly Hair 8%
• Growth Plate 8%
• Mendelian Ratio 8%

Immunology and Microbiology

• Epidermal Growth Factor 100%
• CRISPR/Cas9 50%
• Tumor Necrosis Factor 50%
• Bone Marrow-Derived Macrophage 50%
• Heart Valve 50%
• Cell Surface 50%
• Interleukin-6 Receptor 50%
• Bone Growth 50%
• Fibroblast 50%

Biochemistry, Genetics and Molecular Biology

• Metalloproteinase 100%
• Disintegrin 100%
• Metalloendopeptidase 100%
• Epidermal Growth Factor Receptor 16%
• Macrophage 8%
• Transmembrane Domain 8%
• CRISPR/Cas9 8%
• Sheddase 8%
• Bone Growth 8%
• Tumor Necrosis Factor 8%
• Interleukin-6 Receptor 8%
• Fibroblast 8%