TY - JOUR
T1 - T-Cell‒Mediated Autoimmunity
T2 - Mechanisms and Future Directions
AU - Seiringer, Peter
AU - Garzorz-Stark, Natalie
AU - Eyerich, Kilian
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2022/3
Y1 - 2022/3
N2 - T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in producing autoantibodies. Technological advances have contributed to identifying autoantigens, the Holy Grail of autoimmunity, in many inflammatory disorders of the skin. Novel therapeutic approaches such as chimeric (auto)antibody receptor T cells are a milestone on the way to finding individualized, well-tolerated, targeted therapies. This review summarizes the current knowledge on pathogenesis, immune response pattern‒related ontology, diagnostic approaches, and treatment options of autoimmune skin diseases.
AB - T cells are key drivers of autoimmunity in numerous noncommunicable inflammatory skin diseases by directly harming host tissue or through helping B cells in producing autoantibodies. Technological advances have contributed to identifying autoantigens, the Holy Grail of autoimmunity, in many inflammatory disorders of the skin. Novel therapeutic approaches such as chimeric (auto)antibody receptor T cells are a milestone on the way to finding individualized, well-tolerated, targeted therapies. This review summarizes the current knowledge on pathogenesis, immune response pattern‒related ontology, diagnostic approaches, and treatment options of autoimmune skin diseases.
UR - http://www.scopus.com/inward/record.url?scp=85114984160&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2021.04.032
DO - 10.1016/j.jid.2021.04.032
M3 - Review article
C2 - 34538423
AN - SCOPUS:85114984160
SN - 0022-202X
VL - 142
SP - 804
EP - 810
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 3
ER -