T cell dysfunction and therapeutic intervention in cancer

Caitlin C. Zebley, Dietmar Zehn, Stephen Gottschalk, Hongbo Chi

Publikation: Beitrag in FachzeitschriftÜbersichtsartikelBegutachtung

1 Zitat (Scopus)

Abstract

Recent advances in immunotherapy have affirmed the curative potential of T cell-based approaches for treating relapsed and refractory cancers. However, the therapeutic efficacy is limited in part owing to the ability of cancers to evade immunosurveillance and adapt to immunological pressure. In this Review, we provide a brief overview of cancer-mediated immunosuppressive mechanisms with a specific focus on the repression of the surveillance and effector function of T cells. We discuss CD8+ T cell exhaustion and functional heterogeneity and describe strategies for targeting the molecular checkpoints that restrict T cell differentiation and effector function to bolster immunotherapeutic effects. We also delineate the emerging contributions of the tumor microenvironment to T cell metabolism and conclude by highlighting discovery-based approaches for developing future cellular therapies. Continued exploration of T cell biology and engineering hold great promise for advancing therapeutic interventions for cancer.

OriginalspracheEnglisch
Seiten (von - bis)1344-1354
Seitenumfang11
FachzeitschriftNature Immunology
Jahrgang25
Ausgabenummer8
DOIs
PublikationsstatusVeröffentlicht - Aug. 2024

Fingerprint

Untersuchen Sie die Forschungsthemen von „T cell dysfunction and therapeutic intervention in cancer“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren