Synthesis of Primary Amines: First Homogeneously Catalyzed Reductive Amination with Ammonia

Thoralf Gross, Abdul Majeed Seayad, Moballigh Ahmad, Matthias Beller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

234 Zitate (Scopus)

Abstract

(Matrix Presented) The synthesis of primary amines via reductive amination of the corresponding carbonyl compounds with aqueous ammonia is achieved for the first time with soluble transition metal complexes. Up to an 86% yield and a 97% selectivity for benzylamines were obtained in the case of various benzaldehydes by using a Rh-catalyst together with water-soluble phosphine and ammonium acetate. In the case of aliphatic aldehydes, a bimetallic catalyst based on Rh/Ir gave improved results.

OriginalspracheEnglisch
Seiten (von - bis)2055-2058
Seitenumfang4
FachzeitschriftOrganic Letters
Jahrgang4
Ausgabenummer12
DOIs
PublikationsstatusVeröffentlicht - 13 Juni 2002
Extern publiziertJa

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