Synthesis of new N-analogous corollosporine derivatives with antibacterial activity by laccase-catalyzed amination

Annett Mikolasch, Susanne Hessel, Manuela Gesell Salazar, Helfried Neumann, Katrin Manda, Dirk Gördes, Enrico Schmidt, Kerstin Thurow, Elke Hammer, Ulrike Lindequist, Matthias Beller, Frieder Schauer

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

51 Zitate (Scopus)

Abstract

Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to the basic structure of the N-analogous corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on the straightforward laccase-catalyzed amination of dihydroxylated arenes with N-analogous corollosporines. In biological assays the obtained amination products are more active than the parent compounds.

OriginalspracheEnglisch
Seiten (von - bis)781-786
Seitenumfang6
FachzeitschriftChemical and Pharmaceutical Bulletin
Jahrgang56
Ausgabenummer6
DOIs
PublikationsstatusVeröffentlicht - Juni 2008
Extern publiziertJa

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