@article{ba4a55b5a7204403818c10baf37aeedd,
title = "Studies on the biosynthesis of 2-hydroxy-1,4-benzoxazin-3-one (HBOA) from 3-hydroxyindolin-2-one in Zea mays",
abstract = "The ring expansion of 3-hydroxyindolin-2-one to 2-hydroxy-1,4-benzoxazin-3-one (HBOA) was investigated by labelling experiments. Action of the cytochrome P450 enzyme BX4 from maize on 3-hydroxyindolin-2-one under an 18O2 atmosphere induced production of 2-hydroxy-1,4-benzoxazin-3-one in which the ring oxygen - but not the 2-hydroxy group of HBOA - is labelled. A mechanism for this transformation is proposed.",
keywords = "BX4, Biosynthesis, HBOA, Mono-oxygenase, P450, Ring expansion, Zea mays",
author = "Peter Spiteller and Erich Glawischnig and Alfons Gierl and Wolfgang Steglich",
note = "Funding Information: We thank Dr. Monika Frey, Garching, for suggestions and helpful discussions and Sebastian Gr{\"u}n for preparation of the induced yeast cell culture. This work was supported by SFB 369 of the Deutsche Forschungsgemein-schaft.",
year = "2001",
month = jun,
doi = "10.1016/S0031-9422(01)00037-1",
language = "English",
volume = "57",
pages = "373--376",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Elsevier Ltd.",
number = "3",
}