TY - JOUR
T1 - Small molecule induced toxic human-IAPP species characterized by NMR
AU - Cox, Sarah J.
AU - Rodriguez Camargo, Diana C.
AU - Lee, Young Ho
AU - Dubini, Romeo C.A.
AU - Rovó, Petra
AU - Ivanova, Magdalena I.
AU - Padmini, Vediappen
AU - Reif, Bernd
AU - Ramamoorthy, Ayyalusamy
N1 - Publisher Copyright:
© The Royal Society of Chemistry.
PY - 2020/11/7
Y1 - 2020/11/7
N2 - In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.
AB - In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-β1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.
UR - http://www.scopus.com/inward/record.url?scp=85094982740&partnerID=8YFLogxK
U2 - 10.1039/d0cc04803h
DO - 10.1039/d0cc04803h
M3 - Article
C2 - 33006345
AN - SCOPUS:85094982740
SN - 1359-7345
VL - 56
SP - 13129
EP - 13132
JO - Chemical Communications
JF - Chemical Communications
IS - 86
ER -