TY - JOUR
T1 - Shedding of BAFF/APRIL Receptors Controls B Cells
AU - Meinl, Edgar
AU - Thaler, Franziska S.
AU - Lichtenthaler, Stefan F.
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/9
Y1 - 2018/9
N2 - Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.
AB - Proteolytic shedding of the receptors BCMA, TACI, and BAFFR reduces their cell-surface expression and ligand-mediated survival of B cell subsets. This shedding is executed by protease γ-secretase or by metalloproteases, and is partially dependent on ligand binding and receptor interactions. Shed receptors may serve as biomarkers for autoimmunity and lymphoma.
UR - http://www.scopus.com/inward/record.url?scp=85050662590&partnerID=8YFLogxK
U2 - 10.1016/j.it.2018.07.002
DO - 10.1016/j.it.2018.07.002
M3 - Short survey
C2 - 30072119
AN - SCOPUS:85050662590
SN - 1471-4906
VL - 39
SP - 673
EP - 676
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -