Second generation protocol for muticomponent coupling reactions of aldehydes, amides and dienophiles

Stefan Klaus, Sandra Hübner, Helfried Neumann, Dirk Strübing, Axel Jacobi Von Wangelin, Dirk Gördes, Matthias Beller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

26 Zitate (Scopus)

Abstract

An improved one-pot procedure for the three-component coupling reaction of aldehydes, amides and dienophiles (AAD reaction) has been developed. Compared to known protocols for this type of reaction, the use of aromatic solvents in the presence of dehydrating reagents allows an efficient synthesis of previously not accessible products. Condensation of ubiquitous available aldehydes and amides and subsequent Diels-Alder reactions with dienophiles furnishes endo-selective amino-functionalized hexahydroisoindole-1,3-dione and tetrahydrophthalic acid derivatives in good yield.

OriginalspracheEnglisch
Seiten (von - bis)970-978
Seitenumfang9
FachzeitschriftAdvanced Synthesis and Catalysis
Jahrgang346
Ausgabenummer8
DOIs
PublikationsstatusVeröffentlicht - Juli 2004
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „Second generation protocol for muticomponent coupling reactions of aldehydes, amides and dienophiles“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren