TY - JOUR
T1 - Screening of plant extracts and plant constituents for calcium-channel blocking activity
AU - Neuhaus-Carlisle, K.
AU - Vierling, W.
AU - Wagner, H.
N1 - Funding Information:
The financial support of the Foundation Deutsche Herzhilfe is gratefully acknowledged.
PY - 1997/3
Y1 - 1997/3
N2 - Various constituents isolated from plants with described or suggested antihypertensive, spasmolytic or diuretic activity were tested in an in vitro-guinea pig papillary muscle model for possible calcium-channel blocking activity. Among the isolated compounds some phenylpropanoids of essential oil (e.g. apiol), mono- and sesquiterpene derivatives (e.g. bisabolol-oxide A), naphthoquinones (e.g. juglone, 7-methyljuglone, plumbagin, garlic constituents), some phenolics and alkaloids showed good to moderate activity (IC50:15-100μM). Some of the tested compounds caused a prolonged duration of the contraction, suggesting an additional K+-channel blocking effect.
AB - Various constituents isolated from plants with described or suggested antihypertensive, spasmolytic or diuretic activity were tested in an in vitro-guinea pig papillary muscle model for possible calcium-channel blocking activity. Among the isolated compounds some phenylpropanoids of essential oil (e.g. apiol), mono- and sesquiterpene derivatives (e.g. bisabolol-oxide A), naphthoquinones (e.g. juglone, 7-methyljuglone, plumbagin, garlic constituents), some phenolics and alkaloids showed good to moderate activity (IC50:15-100μM). Some of the tested compounds caused a prolonged duration of the contraction, suggesting an additional K+-channel blocking effect.
KW - Calcium-channel blocking activity
KW - Garlic constituents and alkaloids
KW - Papillary muscle of guinea pig
KW - Phenylpropanoids
KW - Quinones
KW - Terpenoids
UR - http://www.scopus.com/inward/record.url?scp=0002161673&partnerID=8YFLogxK
U2 - 10.1016/s0944-7113(97)80030-x
DO - 10.1016/s0944-7113(97)80030-x
M3 - Article
AN - SCOPUS:0002161673
SN - 0944-7113
VL - 4
SP - 67
EP - 71
JO - Phytomedicine
JF - Phytomedicine
IS - 1
ER -