@inbook{4b83a3c87c674c8aa12f8504eec0c7c5,
title = "RNA interference in mice",
abstract = "Silencing of gene expression by RNA interference (RNAi) has become a powerful tool for functional genomics in mammalian cells. Furthermore, RNAi holds promise as a simple, fast and cost-effective approach to studying mammalian gene function in vivo and as a novel therapeutic approach. This review provides an overview of the progress of RNAi in vivo, with emphasis on systemic/local siRNA delivery, viral shRNA vectors, shRNA vector transgenic mice and conditional systems to control shRNA vectors. Taken together, the data from 80 in vivo studies show that RNAi is a useful tool that offers new opportunities for functional genomics in mice.",
keywords = "Functional genomics, Mouse, RNAi, Transgenic mice, siRNA",
author = "R. K{\"u}hn and S. Streif and W. Wurst",
year = "2007",
doi = "10.1007/978-3-540-35109-2_7",
language = "English",
isbn = "9783540351085",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer Science and Business Media, LLC",
pages = "149--176",
booktitle = "Conditional Mutagenesis",
}