Risk factors for capillary leakage syndrome after bone marrow transplantation

W. Nürnberger, R. Willers, S. Burdach, U. Göbel

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

67 Zitate (Scopus)

Abstract

Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related, unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients after BMT. CLS was defined as unexplained weight gain of > 3% within 24 h and nonresponsiveness to furosemide. CLS occurred in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p = 0.0017) for hematopoietic disorders (n = 54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p = 0.0001) for solid tumors (n = 42). Hematopoietic growth factors and cyclosporin A were no significant risk factors on their own. We conclude that unrelated BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for CLS.

OriginalspracheEnglisch
Seiten (von - bis)221-224
Seitenumfang4
FachzeitschriftAnnals of Hematology
Jahrgang74
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - Mai 1997
Extern publiziertJa

Fingerprint

Untersuchen Sie die Forschungsthemen von „Risk factors for capillary leakage syndrome after bone marrow transplantation“. Zusammen bilden sie einen einzigartigen Fingerprint.

Dieses zitieren