Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Yuchen Xia; Julie Lucifora; Florian Reisinger; Mathias Heikenwalder; Ulrike Protzer

doi:10.1126/science.1254083

Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Yuchen Xia, Julie Lucifora, Florian Reisinger, Mathias Heikenwalder, Ulrike Protzer

Lehrstuhl für Virologie

Technische Universität München

Publikation: Beitrag in Fachzeitschrift › Kommentar/Debatte

20 Zitate (Scopus)

Abstract

Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.

Originalsprache	Englisch
Seiten (von - bis)	1237b
Fachzeitschrift	Science
Jahrgang	344
Ausgabenummer	6189
DOIs	https://doi.org/10.1126/science.1254083
Publikationsstatus	Veröffentlicht - 2014

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Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Abstract

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