Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Carsten B. Schmidt-Weber; Kurt Blaser

doi:10.1016/j.coi.2004.09.008

Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Carsten B. Schmidt-Weber
, Kurt Blaser

Schweizerisches Institut für Allergie- und Asthmaforschung (SIAF), Swiss Institute for Allergy and Asthma Research

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

117 Zitate (Scopus)

Abstract

Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

Originalsprache	Englisch
Seiten (von - bis)	709-716
Seitenumfang	8
Fachzeitschrift	Current Opinion in Immunology
Jahrgang	16
Ausgabenummer	6
DOIs	https://doi.org/10.1016/j.coi.2004.09.008
Publikationsstatus	Veröffentlicht - Dez. 2004
Extern publiziert	Ja

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title = "Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation",

abstract = "Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.",

author = "Schmidt-Weber, \{Carsten B.\} and Kurt Blaser",

note = "Funding Information: This work was supported by grants from the Swiss National Foundation (31-65436.01, 32-100266 and 3100A0-100164), by the Ehmann Foundation, the Saurer Foundation, the Jubil{\"a}umsstiftung der Schweizerischen Lebensversicherungs-und Rentenanstalt f{\"u}r Volksgesundheit und medizinische Forschung and the Ernst-G{\"o}hner Stiftung, Zug.",

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AU - Blaser, Kurt

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N2 - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

AB - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

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AN - SCOPUS:7044284788

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Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Abstract

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