Regression analysis for assessment of myelination status in preterm brains with magnetic resonance imaging

Siying Wang, Maria Kuklisova-Murgasova, Joseph V. Hajnal, Christian Ledig, Julia A. Schnabel

Publikation: Beitrag in Buch/Bericht/KonferenzbandKonferenzbeitragBegutachtung

3 Zitate (Scopus)

Abstract

Myelination is considered an important developmental process during human brain maturation and to be closely correlated with gestational age. Assessment of the myelination status generally requires dedicated imaging, yet the conventional T2-weighted acquisitions routinely obtained during clinical imaging of neonates carry signatures that are thought to be directly associated with myelination. In this work, we propose a method to identify these signatures which could potentially be used to assess brain maturation of preterm neonates directly from T2-weighted magnetic resonance images. First we segment the tissue that is likely to contain myelin from 96 preterm neonates. We then construct a spatio-temporal atlas based on the registered segmentations by fitting a voxelwise logistic regression model. Finally, the atlas is utilized to estimate the gestational ages of individual subjects in a leave-one-out procedure. The logistic model yields a root mean squared error of 10 days, as compared to 13 days for the ages predicted using a kernel regression atlas.

OriginalspracheEnglisch
Titel2016 IEEE International Symposium on Biomedical Imaging
UntertitelFrom Nano to Macro, ISBI 2016 - Proceedings
Herausgeber (Verlag)IEEE Computer Society
Seiten278-281
Seitenumfang4
ISBN (elektronisch)9781479923502
DOIs
PublikationsstatusVeröffentlicht - 15 Juni 2016
Extern publiziertJa
Veranstaltung2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016 - Prague, Tschechische Republik
Dauer: 13 Apr. 201616 Apr. 2016

Publikationsreihe

NameProceedings - International Symposium on Biomedical Imaging
Band2016-June
ISSN (Print)1945-7928
ISSN (elektronisch)1945-8452

Konferenz

Konferenz2016 IEEE 13th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2016
Land/GebietTschechische Republik
OrtPrague
Zeitraum13/04/1616/04/16

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