Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles

Jola Pospech, Anis Tlili, Anke Spannenberg, Helfried Neumann, Matthias Beller

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

31 Zitate (Scopus)

Abstract

A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. C H bond functionalization: A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) C(sp2) bond formation has been achieved.

OriginalspracheEnglisch
Seiten (von - bis)3135-3141
Seitenumfang7
FachzeitschriftChemistry - A European Journal
Jahrgang20
Ausgabenummer11
DOIs
PublikationsstatusVeröffentlicht - 10 März 2014
Extern publiziertJa

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