TY - JOUR
T1 - PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome
AU - Schormair, Barbara
AU - Kemlink, David
AU - Roeske, Darina
AU - Eckstein, Gertrud
AU - Xiong, Lan
AU - Lichtner, Peter
AU - Ripke, Stephan
AU - Trenkwalder, Claudia
AU - Zimprich, Alexander
AU - Stiasny-Kolster, Karin
AU - Oertel, Wolfgang
AU - Bachmann, Cornelius G.
AU - Paulus, Walter
AU - Högl, Birgit
AU - Frauscher, Birgit
AU - Gschliesser, Viola
AU - Poewe, Werner
AU - Peglau, Ines
AU - Vodicka, Pavel
AU - Vávrová, Jana
AU - Sonka, Karel
AU - Nevsimalova, Sona
AU - Montplaisir, Jacques
AU - Turecki, Gustavo
AU - Rouleau, Guy
AU - Gieger, Christian
AU - Illig, Thomas
AU - Wichmann, H. Erich
AU - Holsboer, Florian
AU - Müller-Myhsok, Bertram
AU - Meitinger, Thomas
AU - Winkelmann, Juliane
N1 - Funding Information:
We are grateful to all individuals who participated in this study. We wish to thank J. Favor, B. Pütz and K. Oexle for discussions and R. Feldmann, J. Golic, K. Junghans and B. Schmick for technical assistance. We acknowledge L. Habersack, H. Rhese and J. Schmidt-Evers from the German RLS patient organization for supporting this study. Part of this work was financed by the National Genome Research Network (NGFN). The KORA study group consists of H.-E. Wichmann (speaker), R. Holle, J. John, T. Illig, C. Meisinger, A. Peters and their co-workers, who are responsible for the design and conduct of the KORA studies. The KORA research platform (KORA, Cooperative Research in the Region of Augsburg) was initiated and financed by the Helmholtz Zentrum München, which is funded by the German Federal Ministry of Education and Research and by the State of Bavaria. The Canadian part of the study was supported by a Canadian Institutes of Health Research (CIHR) grant to G.R., J.M. and G.T. D.K. was supported by grant MSM0021620849, and J.V. and K.S. were supported by grant MSM0021620816. Recruitment of Czech controls was funded by grant IGA NR 8563-5, Ministry of Health of the Czech Republic.
PY - 2008/8
Y1 - 2008/8
N2 - We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5′ UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, Pnominal/λ corrected = 5.91 × 10-10, odds ratio (OR) = 1.44; rs1975197, P nominal/λ corrected = 5.81 × 10-9, OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS.
AB - We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5′ UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, Pnominal/λ corrected = 5.91 × 10-10, odds ratio (OR) = 1.44; rs1975197, P nominal/λ corrected = 5.81 × 10-9, OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS.
UR - http://www.scopus.com/inward/record.url?scp=48349142470&partnerID=8YFLogxK
U2 - 10.1038/ng.190
DO - 10.1038/ng.190
M3 - Article
C2 - 18660810
AN - SCOPUS:48349142470
SN - 1061-4036
VL - 40
SP - 946
EP - 948
JO - Nature Genetics
JF - Nature Genetics
IS - 8
ER -