@article{89cad987fd2c4c2080033be97f1a8207,
title = "PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells",
abstract = "Manipulating PTPN2 has potential for advancing immunotherapies. However, it is unclear how PTPN2 impacts the activation, survival, and memory formation of T cells. Flosbach et al. demonstrate that PTPN2-deficient T cells are less dependent on cytokines and show increased programmed expansion, and short-lived effector T cells have enhanced survival and expansion capacity.",
keywords = "GWAS, Protein tyrosine phosphatase non‑receptor type 2 (PTPN2), T cell memory, adoptive T cell transfer, autoimmunity, effector T cells, immunotherapy, phosphoproteome, programmed T cell expansion, single point mutation",
author = "Markus Flosbach and Oberle, {Susanne G.} and Stefanie Scherer and Jana Zecha and {von Hoesslin}, Madlaina and Florian Wiede and Vijaykumar Chennupati and Cullen, {Jolie G.} and Markus List and Pauling, {Josch K.} and Jan Baumbach and Bernhard Kuster and Tony Tiganis and Dietmar Zehn",
note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jul,
day = "28",
doi = "10.1016/j.celrep.2020.107957",
language = "English",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",
}