TY - JOUR
T1 - Psoriasis Pathogenesis
T2 - Keratinocytes Are Back in the Spotlight
AU - Garzorz-Stark, Natalie
AU - Eyerich, Kilian
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/5
Y1 - 2019/5
N2 - Psoriasis is a T helper type 17–mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17–mediated psoriatic phenotype in mice.
AB - Psoriasis is a T helper type 17–mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17–mediated psoriatic phenotype in mice.
UR - http://www.scopus.com/inward/record.url?scp=85064148849&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2019.01.026
DO - 10.1016/j.jid.2019.01.026
M3 - Comment/debate
C2 - 31010530
AN - SCOPUS:85064148849
SN - 0022-202X
VL - 139
SP - 995
EP - 996
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 5
ER -