Prognostic impact of PD-1 and its ligands in renal cell carcinoma

Franziska Erlmeier; Wilko Weichert; Andres Jan Schrader; Michael Autenrieth; Arndt Hartmann; Sandra Steffens; Philipp Ivanyi

doi:10.1007/s12032-017-0961-y

Prognostic impact of PD-1 and its ligands in renal cell carcinoma

Franziska Erlmeier
, Wilko Weichert
, Andres Jan Schrader
, Michael Autenrieth
, Arndt Hartmann
, Sandra Steffens
, Philipp Ivanyi

Lehrstuhl für Pathologie

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

21 Zitate (Scopus)

Abstract

Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.

Originalsprache	Englisch
Aufsatznummer	99
Fachzeitschrift	Medical Oncology
Jahrgang	34
Ausgabenummer	6
DOIs	https://doi.org/10.1007/s12032-017-0961-y
Publikationsstatus	Veröffentlicht - 1 Juni 2017

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title = "Prognostic impact of PD-1 and its ligands in renal cell carcinoma",

abstract = "Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.",

keywords = "PD-1, PD-L1, PD-L2, Prognostic impact, Renal cell carcinoma",

author = "Franziska Erlmeier and Wilko Weichert and Schrader, \{Andres Jan\} and Michael Autenrieth and Arndt Hartmann and Sandra Steffens and Philipp Ivanyi",

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year = "2017",

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doi = "10.1007/s12032-017-0961-y",

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T1 - Prognostic impact of PD-1 and its ligands in renal cell carcinoma

AU - Erlmeier, Franziska

AU - Weichert, Wilko

AU - Schrader, Andres Jan

AU - Autenrieth, Michael

AU - Hartmann, Arndt

AU - Steffens, Sandra

AU - Ivanyi, Philipp

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.

AB - Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.

KW - PD-1

KW - PD-L1

KW - PD-L2

KW - Prognostic impact

KW - Renal cell carcinoma

UR - https://www.scopus.com/pages/publications/85018520209

U2 - 10.1007/s12032-017-0961-y

DO - 10.1007/s12032-017-0961-y

M3 - Review article

C2 - 28432616

AN - SCOPUS:85018520209

SN - 1357-0560

VL - 34

JO - Medical Oncology

JF - Medical Oncology

IS - 6

M1 - 99

ER -

Prognostic impact of PD-1 and its ligands in renal cell carcinoma

Abstract

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