Probing transient non-native states in amyloid beta fiber elongation by NMR

Jeffrey R. Brender; Anirban Ghosh; Samuel A. Kotler; Janarthanan Krishnamoorthy; Swapna Bera; Vanessa Morris; Timir Baran Sil; Kanchan Garai; Bernd Reif; Anirban Bhunia; Ayyalusamy Ramamoorthy

doi:10.1039/c9cc01067j

Probing transient non-native states in amyloid beta fiber elongation by NMR

Jeffrey R. Brender, Anirban Ghosh, Samuel A. Kotler, Janarthanan Krishnamoorthy, Swapna Bera, Vanessa Morris, Timir Baran Sil, Kanchan Garai, Bernd Reif, Anirban Bhunia, Ayyalusamy Ramamoorthy

Professur für Festkörper-NMR-Spektroskopie

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

43 Zitate (Scopus)

Abstract

Using NMR to probe transient binding of Aβ_1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

Originalsprache	Englisch
Seiten (von - bis)	4483-4486
Seitenumfang	4
Fachzeitschrift	Chemical Communications
Jahrgang	55
Ausgabenummer	31
DOIs	https://doi.org/10.1039/c9cc01067j
Publikationsstatus	Veröffentlicht - 2019

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10.1039/c9cc01067j

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title = "Probing transient non-native states in amyloid beta fiber elongation by NMR",

abstract = "Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.",

author = "Brender, {Jeffrey R.} and Anirban Ghosh and Kotler, {Samuel A.} and Janarthanan Krishnamoorthy and Swapna Bera and Vanessa Morris and Sil, {Timir Baran} and Kanchan Garai and Bernd Reif and Anirban Bhunia and Ayyalusamy Ramamoorthy",

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year = "2019",

doi = "10.1039/c9cc01067j",

language = "English",

volume = "55",

pages = "4483--4486",

journal = "Chemical Communications",

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T1 - Probing transient non-native states in amyloid beta fiber elongation by NMR

AU - Brender, Jeffrey R.

AU - Ghosh, Anirban

AU - Kotler, Samuel A.

AU - Krishnamoorthy, Janarthanan

AU - Bera, Swapna

AU - Morris, Vanessa

AU - Sil, Timir Baran

AU - Garai, Kanchan

AU - Reif, Bernd

AU - Bhunia, Anirban

AU - Ramamoorthy, Ayyalusamy

PY - 2019

Y1 - 2019

N2 - Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

AB - Using NMR to probe transient binding of Aβ1-40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19-K28 and a lesser degree of interaction near the C-terminus (L34-G37). This represents a shift away from the KLVFFA recognition sequence (residues 16-21) currently used for inhibitor design.

UR - http://www.scopus.com/inward/record.url?scp=85064217487&partnerID=8YFLogxK

U2 - 10.1039/c9cc01067j

DO - 10.1039/c9cc01067j

M3 - Article

C2 - 30917192

AN - SCOPUS:85064217487

SN - 1359-7345

VL - 55

SP - 4483

EP - 4486

JO - Chemical Communications

JF - Chemical Communications

IS - 31

ER -

Probing transient non-native states in amyloid beta fiber elongation by NMR

Abstract

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