Prevention of toxic effects of cyclosporin on pancreatic b-cells of rats by Rioprostil, a new prostaglandin analogue

M. K. Muller, H. Degenhardt, G. Kloppel, H. Goebell, K. Bergmann, M. Lohr

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

5 Zitate (Scopus)

Abstract

Cyclosporin 5, 10, and 20 mg/kg bw was given to rats once daily intragastrically and caused a dose dependent, significant decrease of glucose dependent insulin release from the arterially perfused isolated pancreas, without affecting animal behaviour, weight gain, microscopic appearances of the pancreas, or kidney function. Subcutaneous injection of a new synthetic prostaglandin analogue Rioprostil 7·5 μg/kg bw twice daily completely prevented the effect of cyclosporin 5 mglkg bw and protected significantly against the effects of cyclosporin 10 and 20 mg/kg bw.

OriginalspracheEnglisch
Seiten (von - bis)1524-1530
Seitenumfang7
FachzeitschriftGut
Jahrgang29
Ausgabenummer11
DOIs
PublikationsstatusVeröffentlicht - 1988
Extern publiziertJa

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