Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Fred Falkenburg; Eliana Ruggiero; Chaira Bonini; David Porter; Jeff Miller; Floran Malard; Mohamad Mohty; Nicolaus Kröger; Hans Jochem Kolb

doi:10.1038/s41409-018-0227-0

Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Fred Falkenburg
, Eliana Ruggiero
, Chaira Bonini
, David Porter
, Jeff Miller
, Floran Malard
, Mohamad Mohty
, Nicolaus Kröger
, Hans Jochem Kolb

Leiden University Medical Centre
Istituto Scientifico San Raffaele
University Vita-Salute San Raffaele
The University of Pennsylvania
University of Minnesota Twin Cities
UPMC Univ Paris
University Medical Center Hamburg-Eppendorf
Kolb Consulting UG

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

15 Zitate (Scopus)

Abstract

Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

Originalsprache	Englisch
Seiten (von - bis)	26-34
Seitenumfang	9
Fachzeitschrift	Bone Marrow Transplantation
Jahrgang	54
Ausgabenummer	1
DOIs	https://doi.org/10.1038/s41409-018-0227-0
Publikationsstatus	Veröffentlicht - 1 Jan. 2019
Extern publiziert	Ja

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title = "Prevention and treatment of relapse after stem cell transplantation by cellular therapies",

abstract = "Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.",

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doi = "10.1038/s41409-018-0227-0",

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T1 - Prevention and treatment of relapse after stem cell transplantation by cellular therapies

AU - Falkenburg, Fred

AU - Ruggiero, Eliana

AU - Bonini, Chaira

AU - Porter, David

AU - Miller, Jeff

AU - Malard, Floran

AU - Mohty, Mohamad

AU - Kröger, Nicolaus

AU - Kolb, Hans Jochem

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

AB - Despite recent advances in reducing therapy-related mortality after allogeneic stem cell transplantation (alloSCT) relapse remains the major cause of treatment failure and little progress has been achieved in the last decades. At the 3rd International Workshop on Biology, Prevention, and Treatment of Relapse held in Hamburg/Germany in November 2016 international experts presented and discussed recent developments in the field. Here, the potential of cellular therapies including unspecific and specific T cells, genetically modified T cells, CAR-T cells, NK-cells, and second allografting in prevention and treatment of relapse after alloSCT are summarized.

UR - https://www.scopus.com/pages/publications/85047343496

U2 - 10.1038/s41409-018-0227-0

DO - 10.1038/s41409-018-0227-0

M3 - Review article

C2 - 29795426

AN - SCOPUS:85047343496

SN - 0268-3369

VL - 54

SP - 26

EP - 34

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 1

ER -

Prevention and treatment of relapse after stem cell transplantation by cellular therapies

Abstract

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