Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

K. Zier; B. Gansbacher; S. Salvadori

doi:10.1016/0167-5699(96)80567-6

Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

K. Zier, B. Gansbacher, S. Salvadori

Mount Sinai School of Medicine

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

81 Zitate (Scopus)

Abstract

Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

Originalsprache	Englisch
Seiten (von - bis)	39-45
Seitenumfang	7
Fachzeitschrift	Immunology Today
Jahrgang	17
Ausgabenummer	1
DOIs	https://doi.org/10.1016/0167-5699(96)80567-6
Publikationsstatus	Veröffentlicht - 1996
Extern publiziert	Ja

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title = "Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy",

abstract = "Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.",

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AB - Recent evidence suggests that T cells from tumor-bearing patients exhibit abnormalities in signal transduction that render them unresponsive to appropriate activation signals. Here, Karen Zier, Bernd Gansbacher and Silvia Salvadori review evidence that gene therapy with interleukin 2 (IL-2)-secreting tumor-cell vaccines may prevent such signaling defects.

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DO - 10.1016/0167-5699(96)80567-6

M3 - Review article

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JO - Immunology Today

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Preventing abnormalities in signal transduction of T cells in cancer: The promise of cytokine gene therapy

Abstract

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