Photothermal deflectometry enhanced by total internal reflection enables non-invasive glucose monitoring in human epidermis

M. A. Pleitez, O. Hertzberg, A. Bauer, M. Seeger, T. Lieblein, H. V. Lilienfeld-Toal, W. Mäntele

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

31 Zitate (Scopus)

Abstract

We present TIR-PTD spectroscopy, an IR-pump/VIS-probe method for the measurement of IR absorption spectra by means of photothermal deflectometry (PTD) enhanced by total internal reflection (TIR). It overcomes the limitations of IR spectroscopy for the study of opaque samples and allows molecular fingerprinting of IR-active liquids or solids. Another important advantage of the presented approach over traditional IR spectroscopy methods is the ability to obtain IR information by means of VIS detection, which is generally much cheaper and easier to handle than IR detection. By application of mid-IR TIR-PTD spectroscopy on human skin in vivo, we are demonstrating the correlation between epidermal- and blood-glucose levels on a type 1 diabetic patient.

OriginalspracheEnglisch
Seiten (von - bis)483-488
Seitenumfang6
FachzeitschriftAnalyst
Jahrgang140
Ausgabenummer2
DOIs
PublikationsstatusVeröffentlicht - 21 Jan. 2015
Extern publiziertJa

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