Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Markus Lauerer; Matthias Bussas; Viola Pongratz; Achim Berthele; Jan S. Kirschke; Benedikt Wiestler; Claus Zimmer; Bernhard Hemmer; Mark Mühlau

doi:10.1002/acn3.51700

Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S. Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

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Abstract

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

Originalsprache	Englisch
Seiten (von - bis)	130-135
Seitenumfang	6
Fachzeitschrift	Annals of Clinical and Translational Neurology
Jahrgang	10
Ausgabenummer	1
DOIs	https://doi.org/10.1002/acn3.51700
Publikationsstatus	Veröffentlicht - Jan. 2023

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title = "Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume",

abstract = "Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.",

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year = "2023",

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doi = "10.1002/acn3.51700",

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T1 - Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

AU - Lauerer, Markus

AU - Bussas, Matthias

AU - Pongratz, Viola

AU - Berthele, Achim

AU - Kirschke, Jan S.

AU - Wiestler, Benedikt

AU - Zimmer, Claus

AU - Hemmer, Bernhard

AU - Mühlau, Mark

PY - 2023/1

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N2 - Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

AB - Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

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JO - Annals of Clinical and Translational Neurology

JF - Annals of Clinical and Translational Neurology

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Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

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