Percentage brain volume change in multiple sclerosis mainly reflects white matter and cortical volume

Markus Lauerer, Matthias Bussas, Viola Pongratz, Achim Berthele, Jan S. Kirschke, Benedikt Wiestler, Claus Zimmer, Bernhard Hemmer, Mark Mühlau

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

1 Zitat (Scopus)

Abstract

Brain atrophy in multiple sclerosis (MS), as measured by percentage brain volume change (PBVC) from brain magnetic resonance imaging (MRI), has been established as an outcome parameter in clinical trials. It is unknown to what extent volume changes within different brain tissue compartments contribute to PBVC. We analyzed pairs of MRI scans (at least 6 months apart) in 600 patients with relapsing–remitting MS. Multiple regression revealed that PBVC mainly reflects volume loss of white and cortical gray matter, while deep gray matter and white matter lesions were less represented. Our findings aid the interpretation of PBVC changes in MS.

OriginalspracheEnglisch
Seiten (von - bis)130-135
Seitenumfang6
FachzeitschriftAnnals of Clinical and Translational Neurology
Jahrgang10
Ausgabenummer1
DOIs
PublikationsstatusVeröffentlicht - Jan. 2023
Extern publiziertJa

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