TY - JOUR
T1 - Peptide Inhibitors of the amyloidogenesis of IAPP
T2 - verification of the hairpin-binding geometry hypothesis
AU - Sivanesam, Kalkena
AU - Shu, Irene
AU - Huggins, Kelly N.L.
AU - Tatarek-Nossol, Marianna
AU - Kapurniotu, Aphrodite
AU - Andersen, Niels H.
N1 - Publisher Copyright:
© 2016 Federation of European Biochemical Societies
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Versions of a previously discovered β-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed.
AB - Versions of a previously discovered β-hairpin peptide inhibitor of IAPP aggregation that are stabilized in that conformation, or even forced to remain in the hairpin conformation by a backbone cyclization constraint, display superior activity as inhibitors. The cyclized hairpin, cyclo-WW2, displays inhibitory activity at substoichiometric concentrations relative to this amyloidogenic peptide. The hairpin-binding hypothesis stands confirmed.
KW - amyloid fibril formation
KW - circular dichroism
KW - cyclic β-hairpins
KW - cytotoxicity inhibition
KW - human pancreatic amylin
KW - thioflavin T fluorescence
KW - type II diabetes
UR - http://www.scopus.com/inward/record.url?scp=84983523244&partnerID=8YFLogxK
U2 - 10.1002/1873-3468.12261
DO - 10.1002/1873-3468.12261
M3 - Article
C2 - 27317951
AN - SCOPUS:84983523244
SN - 0014-5793
SP - 2575
EP - 2583
JO - FEBS Letters
JF - FEBS Letters
ER -
