Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection

Eugene Kroon, Suthat Chottanapund, Supranee Buranapraditkun, Carlo Sacdalan, Donn J. Colby, Nitiya Chomchey, Peeriya Prueksakaew, Suteeraporn Pinyakorn, Rapee Trichavaroj, Sandhya Vasan, Sopark Manasnayakorn, Cavan Reilly, Erika Helgeson, Jodi Anderson, Caitlin David, Jacob Zulk, Mark De Souza, Sodsai Tovanabutra, Alexandra Schuetz, Merlin L. RobbDaniel C. Douek, Nittaya Phanuphak, Ashley Haase, Jintanat Ananworanich, Timothy W. Schacker

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

5 Zitate (Scopus)

Abstract

Starting antiretroviral therapy (ART) in Fiebig 1 acute HIV infection limits the size of viral reservoirs in lymphoid tissues, but does not impact time to virus rebound during a treatment interruption. To better understand why the reduced reservoir size did not increase the time to rebound we measured the frequency and location of HIV RNA+ cells in lymph nodes from participants in the RV254 acute infection cohort. HIV RNA+ cells were detected more frequently and in greater numbers when ART was initiated in Fiebig 1 compared to later Fiebig stages and were localized to the T-cell zone compared to the B-cell follicle with treatment in later Fiebig stages. Variability of virus production in people treated during acute infection suggests that the balance between virus-producing cells and the immune response to clear infected cells rapidly evolves during the earliest stages of infection. Clinical Trials Registration: NCT02919306.

OriginalspracheEnglisch
Seiten (von - bis)2167-2175
Seitenumfang9
FachzeitschriftJournal of Infectious Diseases
Jahrgang225
Ausgabenummer12
DOIs
PublikationsstatusVeröffentlicht - 15 Juni 2022
Extern publiziertJa

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