Abstract
Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use.
Originalsprache | Englisch |
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Seiten (von - bis) | 4487-4491 |
Seitenumfang | 5 |
Fachzeitschrift | Angewandte Chemie International Edition in English |
Jahrgang | 52 |
Ausgabenummer | 16 |
DOIs | |
Publikationsstatus | Veröffentlicht - 15 Apr. 2013 |