Oral disinfectants inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL and induce apoptosis in human oral tumor cells

Martin Gräber, Michael Hell, Corinna Gröst, Anders Friberg, Bianca Sperl, Michael Sattler, Thorsten Berg

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

18 Zitate (Scopus)

Abstract

Chlorhexidine and alexidine have long been used as oral disinfectants by humans. Both compounds inhibit protein-protein interactions mediated by the anti-apoptotic protein Bcl-xL at physiologically relevant concentrations and induce apoptosis in a series of tumor cell lines derived from the tongue and pharynx (see picture). Inhibition of protein-protein interactions is a potential mode of action of drugs in current human use.

OriginalspracheEnglisch
Seiten (von - bis)4487-4491
Seitenumfang5
FachzeitschriftAngewandte Chemie International Edition in English
Jahrgang52
Ausgabenummer16
DOIs
PublikationsstatusVeröffentlicht - 15 Apr. 2013

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