TY - JOUR
T1 - Optogenetics in a transparent animal
T2 - Circuit function in the larval zebrafish
AU - Portugues, Ruben
AU - Severi, Kristen E.
AU - Wyart, Claire
AU - Ahrens, Misha B.
N1 - Funding Information:
CW and KS benefited from a chaire d’excellence from the Ecole des Neurosciences de Paris (ENP), the Atip-Avenir fund from the CNRS and Inserm funded by the Fondation Bettencourt Schueller , the Fondation Institut du Cerveau et de la Moelle épinière (ICM) , the Emergence grant from the Mairie de Paris , the NERF region , the FYSSEN foundation and the International Reintegration Grant (IRG) from the Marie Curie Action and the European Research Council project ‘Optoloco’ . MA was supported by the Howard Hughes Medical Institute and by the Wellcome Trust.
PY - 2013/2
Y1 - 2013/2
N2 - Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.
AB - Optogenetic tools can be used to manipulate neuronal activity in a reversible and specific manner. In recent years, such methods have been applied to uncover causal relationships between activity in specified neuronal circuits and behavior in the larval zebrafish. In this small, transparent, genetic model organism, noninvasive manipulation and monitoring of neuronal activity with light is possible throughout the nervous system. Here we review recent work in which these new tools have been applied to zebrafish, and discuss some of the existing challenges of these approaches.
UR - http://www.scopus.com/inward/record.url?scp=84872863981&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2012.11.001
DO - 10.1016/j.conb.2012.11.001
M3 - Review article
C2 - 23246238
AN - SCOPUS:84872863981
SN - 0959-4388
VL - 23
SP - 119
EP - 126
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -