Ontogeny, differentiation and growth of the endocrine pancreas

Jochen Peters; Anja Jürgensen; Günter Klöppel

doi:10.1007/s004280000208

Ontogeny, differentiation and growth of the endocrine pancreas

Jochen Peters, Anja Jürgensen, Günter Klöppel

Christian-Albrechts-University of Kiel

Publikation: Beitrag in Fachzeitschrift › Übersichtsartikel › Begutachtung

61 Zitate (Scopus)

Abstract

The pancreas develops from the primitive foregut endoderm, which differentiates into ductal, acinar and endocrine cells. This complex process is probably replicated in the adult pancreas when endocrine cell renewal is required, as may be the case in diabetes mellitus. This review describes what is known about the morphogenesis of the endocrine pancreas during ontogeny and the mechanisms regulating its differentiation and growth.

Originalsprache	Englisch
Seiten (von - bis)	527-538
Seitenumfang	12
Fachzeitschrift	Virchows Archiv
Jahrgang	436
Ausgabenummer	6
DOIs	https://doi.org/10.1007/s004280000208
Publikationsstatus	Veröffentlicht - 2000
Extern publiziert	Ja

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title = "Ontogeny, differentiation and growth of the endocrine pancreas",

abstract = "The pancreas develops from the primitive foregut endoderm, which differentiates into ductal, acinar and endocrine cells. This complex process is probably replicated in the adult pancreas when endocrine cell renewal is required, as may be the case in diabetes mellitus. This review describes what is known about the morphogenesis of the endocrine pancreas during ontogeny and the mechanisms regulating its differentiation and growth.",

keywords = "Differentiation, Endocrine pancreas, Growth, Morphogenesis",

author = "Jochen Peters and Anja J{\"u}rgensen and G{\"u}nter Kl{\"o}ppel",

note = "Funding Information: We thank Mami Machida, Yoshiaki Kato and Takuhito Kuwabara for collaboration and providing the figures. Numerical simulations were carried out on VPP5000 at Center for Computational Astrophysics, CfCA of NAOJ. This work is supported by the Grant-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology (RM: 20340040).",

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AU - Jürgensen, Anja

AU - Klöppel, Günter

N1 - Funding Information: We thank Mami Machida, Yoshiaki Kato and Takuhito Kuwabara for collaboration and providing the figures. Numerical simulations were carried out on VPP5000 at Center for Computational Astrophysics, CfCA of NAOJ. This work is supported by the Grant-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology (RM: 20340040).

PY - 2000

Y1 - 2000

N2 - The pancreas develops from the primitive foregut endoderm, which differentiates into ductal, acinar and endocrine cells. This complex process is probably replicated in the adult pancreas when endocrine cell renewal is required, as may be the case in diabetes mellitus. This review describes what is known about the morphogenesis of the endocrine pancreas during ontogeny and the mechanisms regulating its differentiation and growth.

AB - The pancreas develops from the primitive foregut endoderm, which differentiates into ductal, acinar and endocrine cells. This complex process is probably replicated in the adult pancreas when endocrine cell renewal is required, as may be the case in diabetes mellitus. This review describes what is known about the morphogenesis of the endocrine pancreas during ontogeny and the mechanisms regulating its differentiation and growth.

KW - Differentiation

KW - Endocrine pancreas

KW - Growth

KW - Morphogenesis

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M3 - Review article

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JO - Virchows Archiv

JF - Virchows Archiv

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Ontogeny, differentiation and growth of the endocrine pancreas

Abstract

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