Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

Yan Xiao; Luigi Petrucco; Laura J. Hoodless; Ruben Portugues; Tim Czopka

doi:10.1038/s41593-022-01023-7

Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

Yan Xiao, Luigi Petrucco, Laura J. Hoodless, Ruben Portugues, Tim Czopka

Professur für Brain Circuit Function and Dysfunction

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

36 Zitate (Scopus)

Abstract

Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.

Originalsprache	Englisch
Seiten (von - bis)	280-284
Seitenumfang	5
Fachzeitschrift	Nature Neuroscience
Jahrgang	25
Ausgabenummer	3
DOIs	https://doi.org/10.1038/s41593-022-01023-7
Publikationsstatus	Veröffentlicht - März 2022

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10.1038/s41593-022-01023-7

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abstract = "Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell population. The zebrafish optic tectum contains OPCs in regions devoid of myelin. Elimination of these OPCs impaired precise control of retinal ganglion cell axon arbor size during formation and maturation of retinotectal connectivity and degraded functional processing of visual stimuli. Therefore, OPCs fine-tune neural circuits independently of their canonical role to make myelin.",

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Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling

Abstract

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