TY - GEN
T1 - Non-invasive In-vivo sensing of metabolites with a novel Optoacoustic Spectroscope in the SWIR
AU - Seyedebrahimi, M. Mehdi
AU - Pleitez, Miguel A.
AU - Mohajerani, Pouyan
AU - Ntziachristos, Vasilis
N1 - Publisher Copyright:
© SPIE-OSA 2019.
PY - 2019
Y1 - 2019
N2 - In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.
AB - In this work we developed a novel near-infrared two-path optoacoustic spectrometer (NiR-TAOS) that could sense OA intensity changes due to metabolite concentration changes in-vivo. The main aim of dividing the optical path in two is 1) perform real time correction of the laser emission profile of the laser source at different wavelengths and, 2) perform pulse to pulse correction to remove laser beam fluctuation and instability to increase signal to noise ratio. Signal to noise ratio improvement was significant not only at spectral peaks, but also at all other wavelengths. The system can be used for broad applications in biomedical measurements such as various metabolites in the SWIR.
KW - Near-infrared two-path OAS
KW - Non-invasive In-vivo sensing of metabolites
KW - Optoacoustic
KW - Sensitivity and specificity improvement
UR - http://www.scopus.com/inward/record.url?scp=85084461037&partnerID=8YFLogxK
U2 - 10.1117/12.2531625
DO - 10.1117/12.2531625
M3 - Conference contribution
AN - SCOPUS:85084461037
SN - 9781510628397
T3 - Optics InfoBase Conference Papers
BT - European Conference on Biomedical Optics, ECBO_2019
PB - Optica Publishing Group (formerly OSA)
T2 - European Conference on Biomedical Optics, ECBO_2019
Y2 - 23 June 2019 through 25 June 2019
ER -