New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Margot Wenzel; Emilia Bigaeva; Philippe Richard; Pierre Le Gendre; Michel Picquet; Angela Casini; Ewen Bodio

doi:10.1016/j.jinorgbio.2014.07.011

New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Margot Wenzel, Emilia Bigaeva, Philippe Richard, Pierre Le Gendre, Michel Picquet, Angela Casini, Ewen Bodio

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

59 Zitate (Scopus)

Abstract

A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

Originalsprache	Englisch
Seiten (von - bis)	10-16
Seitenumfang	7
Fachzeitschrift	Journal of Inorganic Biochemistry
Jahrgang	141
DOIs	https://doi.org/10.1016/j.jinorgbio.2014.07.011
Publikationsstatus	Veröffentlicht - Dez. 2014
Extern publiziert	Ja

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@article{dae34c6ae1d141368a527056c304c6be,

title = "New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?",

abstract = "A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.",

keywords = "Anticancer agent, Gold complex, Heteronuclear complex, Platinum complex, Thioglucose",

author = "Margot Wenzel and Emilia Bigaeva and Philippe Richard and {Le Gendre}, Pierre and Michel Picquet and Angela Casini and Ewen Bodio",

note = "Funding Information: A.C. thanks the University of Groningen (Rosalind Franklin Fellowship) for funding. COST Action CM1105 is acknowledged for providing opportunities of discussion. E.B. thanks the Conseil R{\'e}gional de Bourgogne (PARI and 3MIM programs) and the Centre National de la Recherche Scientifique ( CNRS ) for financial support. The Minist{\`e}re de l'Enseignement Sup{\'e}rieur et de la Recherche is acknowledged for a Ph. D. grant to M.W. Dr F. Picquet and Ms M.-J. Penouilh are gratefully acknowledged for HR-MS analyses. Prof. A. Quiroga and Dr. M.S. Meier are kindly acknowledged for providing an amount of 9-EtG. ",

year = "2014",

month = dec,

doi = "10.1016/j.jinorgbio.2014.07.011",

language = "English",

volume = "141",

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journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

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T1 - New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties

T2 - Are two metals better than one?

AU - Wenzel, Margot

AU - Bigaeva, Emilia

AU - Richard, Philippe

AU - Le Gendre, Pierre

AU - Picquet, Michel

AU - Casini, Angela

AU - Bodio, Ewen

N1 - Funding Information: A.C. thanks the University of Groningen (Rosalind Franklin Fellowship) for funding. COST Action CM1105 is acknowledged for providing opportunities of discussion. E.B. thanks the Conseil Régional de Bourgogne (PARI and 3MIM programs) and the Centre National de la Recherche Scientifique ( CNRS ) for financial support. The Ministère de l'Enseignement Supérieur et de la Recherche is acknowledged for a Ph. D. grant to M.W. Dr F. Picquet and Ms M.-J. Penouilh are gratefully acknowledged for HR-MS analyses. Prof. A. Quiroga and Dr. M.S. Meier are kindly acknowledged for providing an amount of 9-EtG.

PY - 2014/12

Y1 - 2014/12

N2 - A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

AB - A series of mono- and heterodinuclear gold(I) and platinum(II) complexes with a new bipyridylamine-phosphine ligand have been synthesized and characterized. The X-ray structures of the ligand precursor 4-iodo-N,N- di(pyridin-2-yl)benzamide, and of one gold derivative are reported. All the complexes display antiproliferative properties in vitro in human cancer cells in the range of cisplatin or higher, which appear to correlate with compounds' uptake. Interestingly, studies of the interactions of the compounds with models of DNA indicate different mechanisms of actions with respect to cisplatin. The biological activity study of these complexes provides useful information about the interest of designing multimetallic complexes for enhanced cytotoxic properties.

KW - Anticancer agent

KW - Gold complex

KW - Heteronuclear complex

KW - Platinum complex

KW - Thioglucose

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ER -

New heteronuclear gold(I)-platinum(II) complexes with cytotoxic properties: Are two metals better than one?

Abstract

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