Myokardiale vitalitatsdiagnostik mittels kontrastechokardiographie - Reif fur die klinische routineanwendung?

The most benefit from the evaluation of myocardial viability in coronary artery disease is expected in patients with reduced left ventricular function. There is increasing evidence that the outcome of this patient group is better after revascularization if viable myocardium was present before as compared to patients without pre-reperfusion myocardial viability. Therefore, diagnostic tools for the detection of viable myocardium are of enormous therapeutic and economic relevance. The contrast echocardiographic demonstration of myocardial microvascular integrity has been demonstrated to be a corollary of myocellular viability in the experimental and clinical setting. In animal models of reperfusion in acute myocardial infarction, it could be demonstrated that myocardial echocontrast defects, however, only accurately estimate the extent of microvascular damage and the amount of viable tissue after reactive hyperemia has abated. In patients, immediately after reperfusion of the infarct-related artery in acute myocardial infarction, myocardial areas of no reflow could be detected using contrast echocardiography. It has been shown that these myocardial segments exhibit significantly reduced recovery of regional contractile function weeks after reperfusion. In contrast, regions with myocardial microvascular integrity as defined by contrast echocardiography recover function to a significantly higher degree. Furthermore, in patients with remote myocardial infarction, myocardial opacification by contrast echocardiography indicates myocardial collateral perfusion with preserved tissue viability and a high probability of functional recovery after reperfusion. In patients with chronic coronary artery disease and reduced left ventricular ejection fraction, functional recovery could be predicted by myocardial contrast echocardiography with a very high sensitivity in several studies. The lower specificity of the technique may be due to the fact that recovery of contractile function after reperfusion may not be expected in all segments at rest (which was used as the gold standard for viability evaluation in these studies) but rather during physical or pharmacological stress. Therefore, post-reperfusion demonstration of contractile reserve might be a more adequate criterion for the assessment of diagnostic accuracy of myocardial contrast echocardiography for pre-reperfusion viability detection. So far, for the evaluation of myocardial viability, myocardial contrast echocardiography has been exclusively performed using intracoronary injection of echo contrast media; based on the evidence from various studies, this technique is ready for routine clinical application; the place of venous myocardial contrast echocardiography for this purpose, which is an extremely promising technique, however, remains to be defined.