Mutual antagonism of T cells causing psoriasis and atopic eczema

Stefanie Eyerich; Anna T. Onken; Stephan Weidinger; Andre Franke; Francesca Nasorri; Davide Pennino; Martine Grosber; Florian Pfab; Carsten B. Schmidt-Weber; Martin Mempel; Ruediger Hein; Johannes Ring; Andrea Cavani; Kilian Eyerich

doi:10.1056/NEJMoa1104200

Mutual antagonism of T cells causing psoriasis and atopic eczema

Stefanie Eyerich, Anna T. Onken, Stephan Weidinger, Andre Franke, Francesca Nasorri, Davide Pennino, Martine Grosber, Florian Pfab, Carsten B. Schmidt-Weber, Martin Mempel, Ruediger Hein, Johannes Ring, Andrea Cavani, Kilian Eyerich

Publikation: Beitrag in Fachzeitschrift › Artikel › Begutachtung

199 Zitate (Scopus)

Abstract

The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

Originalsprache	Englisch
Seiten (von - bis)	231-238
Seitenumfang	8
Fachzeitschrift	New England Journal of Medicine
Jahrgang	365
Ausgabenummer	3
DOIs	https://doi.org/10.1056/NEJMoa1104200
Publikationsstatus	Veröffentlicht - 21 Juli 2011

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abstract = "The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.",

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AU - Eyerich, Stefanie

AU - Onken, Anna T.

AU - Weidinger, Stephan

AU - Franke, Andre

AU - Nasorri, Francesca

AU - Pennino, Davide

AU - Grosber, Martine

AU - Pfab, Florian

AU - Schmidt-Weber, Carsten B.

AU - Mempel, Martin

AU - Hein, Ruediger

AU - Ring, Johannes

AU - Cavani, Andrea

AU - Eyerich, Kilian

PY - 2011/7/21

Y1 - 2011/7/21

N2 - The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

AB - The simultaneous occurrence of psoriasis driven by type 1 helper T (Th1) cells and type 17 helper T (Th17) cells and atopic eczema dominated by type 2 helper T (Th2) cells is rare. Here, we describe three patients with co-occurring psoriasis and atopic eczema with an antagonistic course and distinct T-cell infiltrates in lesions from psoriasis and those from atopic eczema. Sensitized patients with psoriasis had a reaction to epicutaneous allergen challenge, with clinically and histologically verified eczema lesions containing a large number of allergen-reactive T cells. These findings support a causative role for T cells triggered by specific antigens in both psoriasis and atopic eczema.

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JO - New England Journal of Medicine

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Mutual antagonism of T cells causing psoriasis and atopic eczema

Abstract

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