Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Daniel Razansky; Niels J. Harlaar; Jan Luuk Hillebrands; Adrian Taruttis; Eva Herzog; Clark Zeebregts; Goitzen Van Dam; Vasilis Ntziachristos

doi:10.1117/12.875271

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

Daniel Razansky, Niels J. Harlaar, Jan Luuk Hillebrands, Adrian Taruttis, Eva Herzog, Clark Zeebregts, Goitzen Van Dam, Vasilis Ntziachristos

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag › Begutachtung

1 Zitat (Scopus)

Abstract

In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

Originalsprache	Englisch
Titel	Photons Plus Ultrasound
Untertitel	Imaging and Sensing 2011
DOIs	https://doi.org/10.1117/12.875271
Publikationsstatus	Veröffentlicht - 2011
Veranstaltung	Photons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, USA/Vereinigte Staaten Dauer: 23 Jan. 2011 → 25 Jan. 2011

Publikationsreihe

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Band	7899
ISSN (Print)	1605-7422

Konferenz

Konferenz	Photons Plus Ultrasound: Imaging and Sensing 2011
Land/Gebiet	USA/Vereinigte Staaten
Ort	San Francisco, CA
Zeitraum	23/01/11 → 25/01/11

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Razansky, D., Harlaar, N. J., Hillebrands, J. L., Taruttis, A., Herzog, E., Zeebregts, C., Van Dam, G., & Ntziachristos, V. (2011). Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. in Photons Plus Ultrasound: Imaging and Sensing 2011 Artikel 789905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 7899). https://doi.org/10.1117/12.875271

@inproceedings{51136fffad8644ba953d7321d41e3427,

title = "Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques",

abstract = "In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.",

keywords = "Atherosclerosis, Carotid plaques, Molecular imaging, Multispectral optoacoustic tomography",

author = "Daniel Razansky and Harlaar, {Niels J.} and Hillebrands, {Jan Luuk} and Adrian Taruttis and Eva Herzog and Clark Zeebregts and {Van Dam}, Goitzen and Vasilis Ntziachristos",

year = "2011",

doi = "10.1117/12.875271",

language = "English",

isbn = "9780819484369",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

booktitle = "Photons Plus Ultrasound",

note = "Photons Plus Ultrasound: Imaging and Sensing 2011 ; Conference date: 23-01-2011 Through 25-01-2011",

}

Razansky, D, Harlaar, NJ, Hillebrands, JL, Taruttis, A, Herzog, E, Zeebregts, C, Van Dam, G & Ntziachristos, V 2011, Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. in Photons Plus Ultrasound: Imaging and Sensing 2011., 789905, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Bd. 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, San Francisco, CA, USA/Vereinigte Staaten, 23/01/11. https://doi.org/10.1117/12.875271

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques. / Razansky, Daniel; Harlaar, Niels J.; Hillebrands, Jan Luuk et al.
Photons Plus Ultrasound: Imaging and Sensing 2011. 2011. 789905 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Band 7899).

Publikation: Beitrag in Buch/Bericht/Konferenzband › Konferenzbeitrag › Begutachtung

TY - GEN

T1 - Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

AU - Razansky, Daniel

AU - Harlaar, Niels J.

AU - Hillebrands, Jan Luuk

AU - Taruttis, Adrian

AU - Herzog, Eva

AU - Zeebregts, Clark

AU - Van Dam, Goitzen

AU - Ntziachristos, Vasilis

PY - 2011

Y1 - 2011

N2 - In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

AB - In this work, we show, for the first time to our knowledge, that multispectral optoacoustic tomography (MSOT) can deliver high resolution images of activatable molecular probe's distribution, sensitive to matrix metalloproteinases (MMP), deep within optically scattering human carotid specimen. It is further demonstrated that this method can be used in order to provide accurate maps of vulnerable plaque formations in atherosclerotic disease. Moreover, optoacoustic images can simultaneously show the underlining plaque morphology for accurate localization of MMP activity in three dimensions. This performance directly relates to small animal screening applications and to clinical potential as well.

KW - Atherosclerosis

KW - Carotid plaques

KW - Molecular imaging

KW - Multispectral optoacoustic tomography

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U2 - 10.1117/12.875271

DO - 10.1117/12.875271

M3 - Conference contribution

AN - SCOPUS:79955519991

SN - 9780819484369

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Photons Plus Ultrasound

T2 - Photons Plus Ultrasound: Imaging and Sensing 2011

Y2 - 23 January 2011 through 25 January 2011

ER -

Multispectral optoacoustic tomography resolves smart probe activation in vulnerable plaques

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