@inproceedings{78664713768940d88603a279c5ef1a5a,
title = "Multi-spectral photo-acoustic molecular tomography resolves fluorochrome distribution with high resolution and sensitivity in small animals",
abstract = "Current non-invasive imaging methods of fluorescent molecular probes in the visible and near-infrared suffer from low spatial resolution as a result of rapid light diffusion in biological tissues. We show that three-dimensional distribution of fluorochromes deep in small animals can be resolved with below 25 femtomole sensitivity and 150 microns spatial resolution by means of multi-spectral photoacoustic molecular tomography. The low sensitivity limit of the method is enabled by using the highly resonant absorption spectrum of a commonly used near-infrared fluorescent molecular probe Alexa Fluor{\textregistered} 750 in order to acquire differential images at multiple wavelengths with tomographic topology suitable for whole-body small animal imaging.",
author = "Daniel Razansky and Claudio Vinegoni and Vasilis Ntziachristos",
year = "2008",
doi = "10.1117/12.764155",
language = "English",
isbn = "9780819470317",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "9th Conference on Photons Plus Ultrasound: Imaging and Sensing 2008 ; Conference date: 20-01-2008 Through 23-01-2008",
}