Molecular characterization, structure and developmental expression of Megane bHLH factor

Jordi Guimera, Daniela Vogt Weisenhorn, Diego Echevarría, Salvador Martínez, Wolfgang Wurst

Publikation: Beitrag in FachzeitschriftArtikelBegutachtung

15 Zitate (Scopus)

Abstract

We report here the full-length sequence identification, molecular characterization, detailed demarcation expression analysis relevant to morphological marker genes and mapping of a bHLH transcription gene, referred to as Megane (Mgn). Mgn protein is structurally related to the neurogenic Drosophila hairy and Enhancer of split (h/E(spl)) proteins. The unique structural properties of Mgn factor in several characteristic residues define the gene as related to h/E(spl), but distinguish it from previously identified mammalian members of the family. Mgn is a single copy gene on mouse chromosome 8 and encodes a 27 kDa protein that functions in the nucleus. First expression of Mgn is detected at mouse embryonic day 9.5 within the most rostral part of the cephalic flexure of the developing midbrain. Later, Mgn expression extends into other alar areas of the midbrain and forebrain, developmentally controlled in a regional specific pattern.

OriginalspracheEnglisch
Seiten (von - bis)65-76
Seitenumfang12
FachzeitschriftGene
Jahrgang377
Ausgabenummer1-2
DOIs
PublikationsstatusVeröffentlicht - 1 Aug. 2006
Extern publiziertJa

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